Introduction: Morbidity and mortality of Thalassemia significantly reduced and nowadays there are more attention to the quality of life and related factors.Considering that thalassemia and its complications impact on quality of life of children, it is still unknown. The aim of this study was investigation of quality of life of Thalassemic children in four domains of physical, social, emotional and school, that compared with the control group.Methods: Thalassemic children (n=40) referred to the special diseases center of Besat hospital selected. Also, healthy children (n=40) that was matched based on age, sex and education selected from their classmate as control group. The standard quality of life questionnaire consisted of two sections used for data collection, the first section included demographic questions (n=9), second section included 23 questions about the quality of life in four dimensions: physical, social, emotional and school. Data analyzed by SPSS v.14 software. Kolmogorov-Smirnov test used for testing normality of the distribution.Results: The mean age of subjects with mean and standard deviation were respectively 13.2±4.26, level of education of the majority of children (45 percent) were elementary school and 50 percent of their fathers were illiterate and 34.5 percent of mothers in elementary level. The majority (67.5 percent) of residents were without private homes (40 percent) and personal vehicles (70 percent). Results related to the quality of life showed that children the quality of life in four domains of physical, emotional, social, and school children with specific thalassemia was lower than control group (P<0.05). Total quality of life in were 1.4±0.69 in children with thalassemia and 9.6±0.14 in healthy children, t -test showed a significant statically relationship (P=0.000).Conclusion: The results showed that children with thalassemia have problems with the quality of life in four domains of physical, social, emotional and school.Therefore planning to promote mental health, participation in social activities, providing the necessary consultations and adaptive solutions along with clinical and therapeutic services in this patients center patients can increase their quality of life.