Background and Aims: The aim of this study was to identifying effective factors on acceptance of information and communication technology among students of Tabriz University in the academic year 2015-2016.Methods: The research method was descriptive. The 360 students of University of Tabriz were selected by Random Stratified Sampling. For collecting data, Technology acceptance model questionnaire (Venkatesh & Bala, 2008) were used. The reliability of questionnaire based on Cronbach's alpha coefficient was.89. For data analysis, structural equation modeling (SEM) via Spss23 and Amos 23 is used.Results: The indexes of The confirmatory factor analysis and structural equation showed that CMIN/df=1.712; CFI=.943 and is RMSEA=0.045. the results of confirmatory factor analysis confirm both the validity and reliability" of the questionnaire and the goodness of the latent variables. The variables: Perceived usefulness (b=.07), perceived ease of use (b=.11), imagine (b=.24), Relevance to academic disciplines (b=.55) Computer Playfulness (b=.58) are positively correlated with technology acceptance; and computer anxiety (b=-.20) is negatively correlated with technology acceptance.Conclusions: The results showed that perceived usefulness and ease of use, imagine, Relevance to academic disciplines, Computer Playfulness are positively and computer anxiety are negatively correlated with technology acceptance. In this study, subjective norm, computer self-efficacy and Perceived Enjoyment have no significant directly relationship with technology acceptance.