In textbooks related to humanistic agents’ role in causing accidents, frequently, it’s discussed on the issue of preparing traits; It means that people, because of possessing some characteristics, have an accident more than others. The research puts emphasis on the personality and big five factor of personality neuroticism, Extraversion, openness, consciousness, and agreeableness-as the assistant agent for identifying the personality characteristics of accident and also for predicting driving behavior and its related consequences. In a post-event research, 40 numbers of drives, the agents of accident in 2008 who were hospitalized in Alzahra hospital, Isfahan, were compared whit a sample consisting of 40 other drives, not being the agent of accident. The questionnaire used in the research was NEO-PI-R. The results were analyzed by the use of MANOVA analysis method, using the soft were SPSS, version. The results showed that the drivers having accidents acquired high scores in neuroticism (p<0.05), agreeableness (p<0.01), and responsibility (p<0.001). The comparison of the two groups who are the agents of accidents and the evidence in the research and the other limited research lead to the tentative result that the personality factor can be one of the significant factors in having accidents. If we can, by doing more research, identify these factors and determine their roles, probably we can have control over this significant event which is detrimental to Iran social health by training drivers and informing them about the effect of these factors.