The aim of the present research was to validate the difficulties in emotion regulation scale in Semnan university students. The research method is descriptive and correlational. Participants were 439 students of Semnan University who were recruited by stratified sampling method. All of them completed the difficulties in emotion regulation scale, Dimensions of anger reactions scale and Spiritual Intelligence scale. confirmatory analysis and Cronbach's alpha coefficient were used for data analysis. The results of the factor analysis indicated that the scale was saturated with the six factors of awareness, impulse control difficulty, clarity, non-acceptance, goal-directed behaviors, and limited access to strategies. The reliability of the scales was acceptance. Also, validity evidences indicated that there was a meaningful relation between the awareness scale, the impulse control difficulties scale, non-acceptance scale, clarity scale, limited access to strategies scale, goal-directed behaviors scale, and impulse control difficulties. There was a relationship between the impulse control difficulties, limited access to strategies, and goal-directed behaviors and range of anger-eliciting situations. Limited access to strategies had the highest correlation with hostile outlook; goal-directed behaviors had the highest correlation with internal anger; awareness had the highest correlation with external anger negatively; impulse control difficulties had the highest correlation with perception of being negatively; and goal-directed behaviors has the highest correlation with spiritual life negatively. Finally, with regard to reliability, validity, administering easy, scoring, and practicality, the difficulties in emotion regulation scale in the students can be used as a valid tool.