The purpose of this research was to investigate the predictors of cardiovascular disease and type 2 diabetes in Ahwaz. For this purpose 450 subjects (including 3 samples, 150 normal and 300 patients) were selected randomly from all diabetic and cardiovascular patients who were referred to governmental and private therapeutic centers in Ahvaz. The normal group was selected from the above-mentioned centers. The instruments used in this study were: Connor-Davidson Resilience Scale, NEO Five-Factor Inventory, Lifestyle Questionnaire & Socioeconomic Status Inventory and Clinical tests. For data analysis multinomial logistic regression was used. The results showed that resilience, neuroticism, extraversion, lifestyle and blood sugar are predictors of type 2 diabetes and resilience, neuroticism, extraversion, conscientiousness, lifestyle and socioeconomic status are predictors of cardiovascular disease. Conscientiousness, socioeconomic status, family history, weight, blood pressure and blood factors (LDL, HDL, TG and Cholesterol) could not predict type 2 diabetes. In addition family history, weight, blood pressure and blood factors (LDL, HDL, TG, Cholesterol), were not significant predictors of cardiovascular disease.