In the recent decades women's entrepreneurship issues have been concerned by the official authorities in order to solve the women's unemployment problem. Although in the past; they did not distinguish between the factors affecting men and women entrepreneurship. But with regard to personality and cognitive differences between men and women, the researchers gradually have differed between the factors affecting men and women entrepreneurship. Since the clothing industry of Yazd is one of the oldest industries in which women's ability to have been exhibited, our purpose in this paper was to identify the internal and external factors affecting women's entrepreneurial activities and studying the relationship between them and the influence of these factors. For this purpose the researcher designed a questionnaire with 55 items. The statistical sample included all the women who have been done entrepreneurship in Yazd clothing industry. In order to test research hypothesis, regression analysis was implemented. Results showed that internal factors including individual attributes, recognizable attributes, role pattern, social culture, organizational components had significant direct linear relationship and environmental components including accessibility of resource and environmental dynamism have nonlinear relationship with woman’s entrepreneurship. Notable point was the mediator roles of environmental factors in relationship to other variables.