Background and Aim: Patients with periodontitis have more risk factors for cardio - vascular diseases in comparison with healthy people. Considering higher prevalence of cardio-vascular and gingival inflammatory diseases in the society, the present study was carried out to evaluate the means of CBC, CRP, and coagulation factors as possible risk factors of cardio- vascular diseases in patients with gingivitis.Methods &Materials: In this case - control retrospective study, 40 male patients (20-25 years old) referred to Isfahan Dental School, who were selected by non-randomized sample method, were divided into 2 groups: group 1: gingivitis cases & group 2: controls (healthy gingiva). The patients underwent clinical examinations and their bleeding index (CBI) was recorded. Blood sampling was carried out in the patients meeting the study criteria and VII - factors were investigated. Data were analyzed statistically by t-test and ANOV A.Result: RBC was 5.31x106 and 5.08x106 in case and control samples, WBC was 6.35x103 and 6.16x103 in cases and controls and HB was 13.52 and 13.93 gr/dlit in case and control groups. Hematocryte, CRP, fibrinogen and VII factor were respectively 42.72%, 2.05, 215.3 and 176 incases and 43.07%, 2.04, 183.5 and 181 mg/dlit in controls. No significant differences were found between two groups in these factors.Conclusion: The results showed no significant differences between the patients having gingivitis and healthy gingival, but due to a strong probability for the bacteria and their products to enter the blood in gingivitis and aggravating atherosclerosis, it is recommended to inform the patients and society about these risk factors.