This study was carried out to investigate the relationship of self-criticism, social anxiety, and fear of failure with internalized shame in students of Shahid Chamran University, Ahvaz, Iran. 82 males and 100 female's students (total, 182) were selected by stratified random sampling. For data collection of social interaction anxiety, Fear of Failure, self criticism, and internalized shame scales were used. Data analysis was conducted using correlation coefficient and multiple regression method. The coefficients of Cronbach's alpha reliability of the four scales were 0.83, 0.80, 0.79, and 0.90, respectively. The findings indicated that self-criticism, social anxiety, and fear of failure have positive significant relationship with internalized shame. Moreover, self-criticism, and social anxiety were positive predictors of shyness. The results support the idea that self-criticism and social anxiety have important roles in predicting student's internalized shame.