Background: RPE scale can be used for self-assessing worker’ s abilities in the workplace. When participants perform a task which transcends their ability, or the grip strength is not appropriate, they experience muscular tension and fatigue. Hand grip is a factor used for preventing muscular skeletal disorders in the upper limb. This study aimed to evaluate the relation between RPE and handgrip strength in female students. Methods: This cross-sectional study was performed among 82 young female students enrolled using simple random sampling. The Borg Scale, a dynamometer, pinch gauge, and treadmill were used to assess the RPE, grip strength, pinch strength, and workload, respectively. Participant’ s grip endurance was specified through determining the maximum time (in seconds) that she could continue applying one-third of the maximum voluntary contraction. Data analysis was carried out by SPSS 20, and using Pearson and Spearman correlation coefficients. Results: The findings indicated that there was an inverse relation between RPE with grip (P = 0. 011), pinch strength (P= 0. 020) and age (P=0. 005). Moreover, there was a direct relation between the RPE and heart rate (P=0. 048). But, no significant relation was observed between the RPE with grip and pinch endurance, height, or BMI. Conclusion: Based on the results, in jobs that require high grip and pinch strength, people with low RPE should be employed to reduce fatigue and muscular discomfort and improve health.