The current study investigated the stressors of some of their related factors in high school students in Ardabil city and the. In one cross sectional study, 157 persons were selected through multistage random cluster sampling frome among high school students population in Ardabil during 2010-2011 school year. They responded to the demographic and the adolescent stress questionnaires. The collected data were analyzed by t test, one way ANOVA and the Pearson correlation test. The results showed that stressors related to concern about the future, not enough money to buy the wanted things, having to make decisions about future work or education, putting pressure on self to meet future goals and being ignored or rejected by the loved person were respectively the main five stressor of the subjects. The stress severity of romantic relationships and peer pressure factors were higher in the female students and the stress severity of future uncertainty and school/leisure conflict factors were higher in the male students. Stress of future uncertainty had high severity in weak socio-economic situation. The stressors of the future uncertainty and school/leisure conflict were related to the age. These results reveal that high school students are at risk for experiencing multiple stressors. This suggests the importance of training stress management skills in school environments.