JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES
Year:2022 | Volume:10 | Issue:2|Papers Count:8

Background & Aim: Excessive use of antibiotics has significantly increased resistance to common antibiotics in the treatment of urinary tract infections. In the present study, antimicrobial efficacy of chitosan nanoparticles and peptide IDR-1018 was evaluated against P. aeruginosa isolates. Methods: In the present study, 20 resistant and 20 sensitive P. aeruginosa isolates to imipenem were collected from patients with urinary tract infections. The ability of biofilm formation and the presence of three genes involved in biofilm production including algD, pslD and pelF in the isolates were determined by crystal violet and PCR methods, respectively. The anti-bacterial effect of imipenem, antimicrobial peptide IDR-1018 and chitosan nanoparticles was evaluated by determining the MIC by microdilution broth method. Results: The ability of biofilm formation in the isolates was weak (10%), moderate (35%) and strong (55%). The frequency of presence of three genes related to biofilm formation including algD, pslD and pelF was 90%, 80% and 75%, respectively. MIC values for the isolates were 16-168 μ, g/ml for imipenem, 40 and 80 μ, g/ml for peptide IDR-1018, 750 and 375 μ, g/ml for chitosan nanoparticles, respectively. Conclusion: Finding alternative approaches such as antimicrobial peptides and nanoparticles can be effective in treatment of P. aeruginosa infections. The results of our study showed that peptide IDR-1018 and chitosan nanoparticles alone or in combination with imipenem can be considered as a treatment strategy.

Background & Aim: In recent decades, much attention has been paid to the application of exercise and herbal medicine in the elimination of free radicals caused by obesity. The aim of this study was to investigate the effect of six weeks of aerobic training and supplementation of pomegranate peel extract on the activity of liver enzymes in obese rats. Methods: 30 female Wistar rats were randomly divided into 5 groups: control, obese, obese+ aerobic exercise, obese+ pomegranate peel extract, obese+ aerobic exercise+ pomegranate peel extract. Obesity was induced by gavage of 0. 5 ml per 100 g of body weight of palm oil frying for 4 weeks (5 days a week). The aerobic training program was performed on a treadmill for six weeks (five 30-minute sessions per week with an intensity of 50 to 60% Vo2max). Pomegranate peel extract at a dose of 60 mg per kg was administered by gavage in the morning for 6 weeks. Feresh method was used to prepare serum samples and determine ALT, AST and ALP values of liver tissue and the data were analyzed by two-way analysis of variance at a significance level of 0. 05. Results: Induction of obesity significantly increased the activity of AST, ALT and ALP enzymes in the liver (P <0. 05). The main effect of aerobic exercise, the main effect of pomegranate peel extract and the interactive effect of aerobic exercise and pomegranate peel extract on all three liver enzymes of obese female rats were significant (P <0. 05). The most significant decrease in AST and ALT enzymes was observed when combining aerobic exercise and pomegranate peel extract. However, there was no significant difference in the reduction of liver enzyme ALP between the three experimental groups (P> 0. 05). Conclusion: The anti-inflammatory and antioxidant properties of pomegranate peel extract and aerobic exercise modulate the levels of biomarkers or compensate for the impaired liver enzymatic activity in obese female subjects after six weeks of intervention.

Background & Aim: Despite the high prevalence of the problem in society, people with pelvic floor disorders are less likely to seek medical services. Various studies stated that one of the important problems with providing medical services to people with pelvic floor disorders is not paying attention to their preferences and expectations. Therefore, this study was conducted with the aim of exploring the experiences of women with pelvic floor disorders with received medical services. Methods: The present study was conducted by designing the conventional qualitative content analysis approach of Graneheim and Lundman on 24 women with pelvic floor disorders. The participants were selected with maximum diversity in a purposeful manner, taking into account the entry criteria, including suffering from any type of pelvic disorder according to the person's own statements, the ability to remember and clearly express experiences, being Muslim and Iranian. Data collection was done with semi-structured in-depth interviews and continued until data saturation. The interviews were digitally recorded and then coded word by word in MAXQDA10 software. Analysis of data is done simultaneously and continuously with the collection of information. Results: After categorizing and coding the data, one main themes named "weakness of the treatment system in disorder management" were extracted. This category has eight sub-categories including insufficient educational services to relieve symptoms, disregarding the rights of clients, the inability of the system to gain people's trust, lack of proper insurance coverage, imposing financial burden on the family. Conclusion: There are weaknesses in the treatment system for pelvic floor disorders, which can be a reason for not using the services optimally. It is necessary to plan for people with pelvic floor disorders in such a way getting more insurance support and comprehensive training. Policymakers should provide better quality services, taking into account the rights of the clients and gaining the satisfaction and trust of the patients.

Background & Aim: Many researches have investigated the relationship between worry and anxiety. Among these, Wells' metacognitive model states that patients with generalized anxiety disorder have positive beliefs about their worries that they refer to it as a useful tool to deal with the threat. Thus the aim of this research was investigating the mediating role of metacognition in the relationship between worry and symptoms of generalized anxiety. Methods: This study is correlational research. The sample of this study included 246 students of Kashan universities in 2017-2018 academic year. To measure variables Pennsylvania State Worry Questionnaire (PSWQ), brief measure for assessing generalized anxiety disorder: GAD-7 and Metacognition Questionnaire-30 (MCQ-30) were used. Then, the data were analyzed using the SPSS-22 and AMOS-22 software. Results: Findings showed a significant relationship between worry and anxiety (r=0/53, P<0. 01) worry and metacognition (r=0/49, P<0. 01), anxiety and metacognition (r=0/53, P<0. 01). The results of the structural equation modeling showed the mediating role of metacognition in the relationship between worry and anxiety. But, path coefficient of positive metacognition and anxiety was not significant, then it was removed from the model. Conclusion: Overall, metacognition plays a mediating role in the relationship between worry and anxiety. These results seem to be applicable in the individual, family, educational, therapeutic and interpersonal mental health.

Background & Aim: Today, health care systems are focused on the patient. The level of patient satisfaction with the quality of nursing care received is one of the main components of quality management in the hospital system. This study aimed to determine the satisfaction of inpatients with the quality of nursing care in the internal wards in medical training centers affiliated with Tabriz University of Medical Sciences. Methods: This study is a cross-sectional descriptive study that was conducted with the participation of 197 eligible patients in 2018 in seventeen medical wards of hospitals affiliated with Tabriz University of Medical Sciences. Patients were sampled using a proportional random method. Data were collected using standard tools. Data analysis was done with spss software version 13 and descriptive and inferential statistics. Results: The total average satisfaction of patients is 187. 31(21. 76) from the range of obtainable scores (41-287) and the highest average satisfaction score is related to the respectful treatment of the nurse with the patient and the lowest score is related to the conflict between the words of doctors and nurses. Conclusion: In this study, patients' satisfaction with nursing care was average. The lowest score was related to the conflict between the words of doctors and nurses that with the planning of nursing managers and doctors, a step can be taken to improve the quality of nursing care and patient satisfaction.

Background & Aim: Job burnout is one of the critical and influential factors in personal behavior and organizational performance. There are many factors affecting job burnout and improving it. Social capital and organizational commitment are some of these factors. The present study was conducted with the aim of investigating the effect of social capital and organizational commitment on the burnout of environmental health workers in Qom health centers. Methods: This descriptive-correlational study was conducted in 2019 with the participation of 384 environmental health workers of Qom health centers. The sample size was determined using Cochran's formula. Sampling was by cluster random sampling method. Standard questionnaires of social capital, organizational commitment and job burnout were used to collect data. Data were analyzed using SPSS version 23, software and LISREL version 32 software. Results: According to the data, the effect of social capital on job burnout (r =-0. 37), the effect of social capital on organizational commitment (r = 0. 66) and the effect of organizational commitment on job burnout (r =-0. 48) were significant. Conclusion: Social capital and organizational commitment are effective in reducing the job burnout of participants. Therefore, in order to reduce employee burnout, specific planning should be done to improve social capital and their commitment.

Background & Aim: The corona virus epidemic has created significant economic effects on a global and national scale. Despite these effects, no evidence was found that could investigate the impact of this disease on business activities, especially from the accounting perspective. Therefore, this research was conducted with the aim of investigating the relationship between the disclosure of the financial effects of Corona and the future performance of companies admitted to the Tehran Stock Exchange. Methods: The present research is a descriptive study. To conduct the study, the information of 117 companies that disclosed the Corona issue in information conferences available on the Kodal website during the years 1398 to 1400 were used. Results: The findings of the research showed that the disclosure of Corona has a negative and significant relationship with future sales, operating profit and net profit, and a positive and significant relationship with future operating cash flow. In addition, the amount of corona disclosure has a positive and significant relationship with short-term abnormal stock returns. Conclusion: In general, the companies that have disclosed and provided more information about the financial effects of Corona, despite the weakening of the company's performance, their operating cash flow has increased, and investors have shown a positive reaction to the discussions related to Corona during the presentation of conferences.

Background & Aim: Content analysis (CA) is a widely used to extract the meanings in qualitative studies. Different approaches and methods have been used to perform CA in nursing studies, and their identification can support the selection of an appropriate method in future research. Therefore, the present narrative review examined the approaches and methods used to analyze contents performed by Iranian nurses. Methods: The current study is a narrative review that was conducted in the two stages. In the first stage, in order to achieve the types and frequency of CA approaches and methods, Persian and English databases were searched without time limit until January 2022. In the second step, after identifying them, by referring to the texts where each of the approaches and methods were comprehensively explained, we determined their characteristics, including the number of steps and the details of each one. Results: The results showed the most used CA approach was the inductive of Granheim and Lundman (135 articles, 43. 97%). There were also studies (111 articles, 36. 16%) used the inductive approach,But they did not mention their method. Myring's method had the most variety in terms of different (nine) CA. Hsieh and Shannon have also proposed three inductive, deductive, and summative approaches to perform the CA. Conclusion: The results found both the inductive and deductive approaches and the eight different methods were used by the Iranian nurse researchers for CA. Although the methods such as Graneheim and Lundman, Elo and Kyngas and Hsieh and Shannon have been most used by the researchers, it seems Myring's method can pay more attention from researchers due to the variety of CA.