Background and Objectives: Marital burnout shows that couples are bored and tired of marriage. Identifying factors causing marital burnout are important to enrich marital life. Therefore, the aim of this study has been to predict marital burnout based on personality traits and sexual intimacy in nurses.Materials and Methods: In this correlational study 159 married female nurses working in three selected private hospitals in Tehran in 2014 were chosen by stratified random sampling. To collect data, we used Gordon Personality Inventory (GPI), Sexual Intimacy Inventory (SII) and Couple Burnout Scale (CBS). Data were analyzed by Pearson's correlation coefficient and inter-multiple regression analysis.Results: Results of the data analysis showed that there was a significant relationship between marital burnout, sexual intimacy and personality traits of neuroticism, extraversion and conscientiousness (P<0.05), but there was not a significant relationship between agreeableness and openness (P>0.05). Also, results of the analysis showed that there was a significant relationship between sexual intimacy and personality traits of neuroticism, extraversion, agreeableness, and conscientiousness (P<0.05) but it did not have a significant relationship with openness (P>0.05). In general, results of the regression showed that personality traits and sexual intimacy specify %41.6 of marital burnout.Conclusion: According to the research results, training and counseling sexual intimacy and personality traits may prevent marital burnout.