Introduction: Mindfulness is a new concept which has been paid into attention in recent years for treatment of many psychiatric disorders, psychiatrists and psychologists. Using the techniques of mindfulness involves using additional information on how the components of mindfulness act in each psychological disorders. The aim of this study was to compare components of mindfulness in three groups of patients with major depression, generalized anxiety disorder and normal individuals.Materials and Methods: The study universe included all patients with major depressive disorder and generalized anxiety disorder who were referred to counseling center in Tehran. Of these, 30 patients with a diagnosis of major depressive disorder and 30 patients with a diagnosis of generalized anxiety disorder were selected by convenience sampling. A group of 30 normal subjects who were free of major depressive disorder and generalized anxiety University of Medical Sciences were selected from the staff. People in all three groups (depressed, anxious and normal) in terms of age, gender, lack of physical illness and lack of other mental diseases were matched. The instruments used in this study included the Beck Depression Inventory, Spielberger State Anxiety Inventory, and five components of mindfulness and health assessment questionnaire Memphis, Pisa, Paris and San Diego. In order to analyze the research data, descriptive statistics mean and standard deviation and inferential statistics multivariate analysis of variance MANOVA)) and Tukey tests were used.Results: The results showed that among the three groups, there are significant differences in the components of mindfulness. In other words, the components observe, describe and act with awareness among anxious and depressed patients and normal people. A significant difference was seen in terms of non-judgmental mindfulness, among depressed, anxious and dianxious patients and normal individuals. Also, in terms of the component lack of reaction, the difference was significant between groups the groups anxious-depressed, anxious-normal and depressed-normal. Also, the depressed people gained a higher score in affective temperament scales compared to anxious and normal ones and difference of these scores was significant in terms of cyclothymia and irritability.Conclusion: Based on the results of this study, it can be concluded that anxious and depressed patients have a poorer functioning compared to normal people in terms of mindfulness and their affective temperament scores were far higher than those of normal people. Therefore, the mindfulness-based treatments can facilitate the treatment process and improve symptoms of such patients, emphasizing on these components.