Visfatin is a newly discovered adipokine which is highly expressed in visceral adipose tissue and is associated with obesity. But the effect of exercise training on its levels is inconsistent. The aim of this study is to investigate the effect 8 week of combined aerobic-resistance exercise training on serum visfatin levels and anthropometric indices in obese young girls. 24 obese female university students (mean age 20 to 25 years, body mass index (BMI)≥ 30 kg/ m2) who did not participated in any regular training program. They had no previous history of cardiovascular and respiratory, renal, surgical, as well as chemical or hormonal drugs. These subjects were randomly divided into combined training (n=12) and control (n=12) groups. The combined exercise training program includes a combination of resistance training (3 sessions per week, 60-80% 1-RM, 7 stations, 3 set 8-12 repetitions), and aerobic training (3 sessions per week, 60 to 80 percent of vo2max, 25 to 40 minutes of activity). For surveying plasma exchanges of visfatin blood samples were taken in fasting state before and after 8 weeks of exercise training. Serum concentrations of visfatin were measured by ELISA using a human kit of Eastibiopharm. Results showed that in combined exercise training group, Visfatin had reduced significantly compared with control groups (p=0/005). Also BMI, weight, waist circumference, WHR in combined exercise training group, compared with control groups reduced significantly (p<0. 05). Overall, it appears that 8 week of combined exercise training can decrease visfatin level in obese young girls through reducing body weight, waist circumference, WHR and body mass index.