A 42-day rearing trial was conducted to examine the enrichment of Artemia urmiana nauplii with vitamins C (Ascorbyl-6-Palmitate) in combination with unsaturated fatty acids (EPA 18% and DHA 12%) on growth, survival and stress resistance of Beluga, Huso huso larvae. Beluga larvae were distributed into five treatments at the first feeding stage and three tanks were assigned to each diet. The test treatments were as follows: Artemia urmiana enriched with HUFA+10%, 20% and 30% vitamin C (C1, C2 and C3 groups, respectively), Artemia enriched with HUFA without vitamin C (HUFA group) and non-enriched Artemia (control). All treatments were fed with non-enriched Artemia for the initial 5 days after the first feeding and then fed with enriched Artemia for 7 days. After the period of enrichment, larvae were fed with daphnia from the 13th to the 40th day. At day 40, submersion in salt water (12 ppt) was performed to evaluate larvae resistance to salinity stress. Blood samples were obtained after 24 and 48 hours salinity stress in order to evaluation of hematocrit index. Growth factors showed comparable differences between groups. The highest and the lowest growth was observed in C3 and control treatments, respectively (P<0.05). Survival rate was not significantly different between groups during experimental period (P>0.05). Mortality rate was statistically different in salinity stress after 2 days and mortalities were lower in enriched groups than non-enriched (P<0.05). There was no comparable difference in hematocrit index under stress conditions (P>0.05). These results indicated that the enrichment of Artemia with essential fatty acids and vitamin C can improve some growth and stress tolerance factors in great sturgeon (Huso huso) larvae.