Background and objective: The purpose of this study is to analyze the impact of information technology and organizational culture on human resource productivity in Ghavamin Bank of Kermanshah province. Method: The statistical population includes 386 employees and 191 people were selected as a sample by simple random sampling using Morgan table. Therefore, this descriptive-survey research is of correlation type. For data collection, the information technology questionnaire of Martinez Lawrence et al. (2004), Deninson Organizational Culture (2000) and Hershey & Smith (1980) Manpower Productivity Questionnaire were used. Validity (content, convergent, divergent) and reliability (factor load, composite reliability coefficient, Cronbach's alpha coefficient) of the questionnaires indicate that the measuring instruments have good validity and reliability. Findings: The results of testing the hypotheses by SMART-PLS software and using t-test statistics and path coefficients (β ), showed that information technology has a strong, direct and significant effect on organizational culture, organizational culture has a strong effect on human resource productivity, and meaningful and also information technology has a weak, direct, indirect and significant effect on human resource productivity. On the other hand, organizational culture plays a mediating role in the impact of information technology on human resource productivity. On the other hand, information technology can be used as a moderating variable to enhance the positive effect that organizational culture has on human productivity. Conclusion: Organizations, especially Ghavamin Bank, in order to improve the productivity of their human resources, should take steps to improve their organizational culture, and this requires attention to information technology.