Iranian Journal of Diabetes and Metabolism
Year:2016 | Volume:16 | Issue:1 |Papers Count:7

Background: Cardiomyopathy is a side effect caused by diabetes. Prolonged hyperglycemia gives rise to an increase in the expression of the receiver gene RAGE subsequently triggering pathogenesis cardiac signaling pathways in the heart of rats with type II diabetes. The present paper aims to examine how a 12 week Resistance training on gene expressions RAGE, ICAM, VCAM in the heart of diabetic rats with STZ.Methods: 16 male Wistar rats with weight mean ranging from 200±20 g were randomly assigned to two groups of Resistance diabetes (n=8) and control diabetes (n=8) and were kept under lab circumstances. A 12 week Resistance training was administered with the experimental group and 48 hours after the end of the last training session the rats were made unconscious and examined. Their hearts were, afterwards, cut out and the extent of gene expressions RAGE, ICAM, VCAM in the left ventricular heart was measured using Real time-PCR method.Results: The results indicated there was a significant difference between left ventricular heart of the Resistance diabetes and that of control diabetes in terms of gene expression RAGE, yet no significant difference was detected between the two groups in terms of gene expressions ICAM, VCAM.Conclusion: According to the results, in seems that Resistance trainings effectively reduce gene expressions RAGE and reduction pattern but non-significant in the Gene ICAM, VCAM in left ventricular heart of diabetic rats and therefore can be considered an effective way in reducing pathogenesis cardiac signaling pathways in the heart of rats with type II diabetes.

Background: Type 2 diabetes is a metabolic disorder characterized by high blood sugar levels that can damage nerves. Many organs are affected, especially the foot that leading to loss of sensation. These factors make favorable conditions for the development of diabetic foot ulcers. Polymorphisms (Thr399Ile) of Toll Like Receptor4 (TLR4) gene due to malfunction of TLR4 protein which plays an important role in immunity. The purpose of this study was to determine the parameters which are affecting the imbalance resulting in chronic inflammation and wound healing. By showing the relationship between single nucleotide polymorphism (Thr399Ile) of TLR4 gene with diabetic foot ulcer we can identify a biomarker for prediction of diabetic foot ulcer.Methods: This is a case-control study. Single nucleotide polymorphisms of TLR4 gene were genotyped by hit Tetra ARMS PCR technique. In this study, 100 and 120 diabetic patients with and without foot ulcer were selected as the cases and controls, respectively.Results: The Chi-square test revealed significant difference in frequency of TT, CC and TC alleles of (Thr399Ile) between case and control groups (P=0.021).Conclusion: According to this study, there is a relationship between single nucleotide polymorphisms (Thr399Ile) of TLR4 gene with diabetic foot ulcer in type 2 diabetes patients.

Background: On time diabetes diagnosis dramatically reduces the many injuries and damage in the community. Diabetes is a disease that requires a lot of care in addition to prevention, such as prediction the correct level of blood sugar fluctuations. The most important complications of such disease are anesthesia, coma and even death at final. Today, in these patients, determining the correct dose of insulin is based on the experience and knowledge of physicians along with the interaction of patients with them, although human error is inevitable.Methods: This study includes 124 patients and 188 healthy suspects were examined based on 21 features which hold by 7 features for diagnosis and 14 features for predicting insulin dose. The proposed system was presented to identify or diagnose the disease at first, and finally the correct doses of insulin for patients have been determine. The proposed system has two stages (which include diagnosis and prediction) and several subsystems. In the diagnosis phase, some sub systems such as the Fuzzy system for the purpose of accurately estimating the disease progression in patients and the decision tree (DT) for the preparation of rules in the fuzzy system (the process of mapping the attribute space (individuals) to the output (the diagnostic result)) have used. Also, in the prediction phase of insulin dose, the BPSO algorithms are used to select the best features. Classification algorithms (SVMs) are used to categorize effective to non-effective and adaptive artificial neuropsychological (ANFIS) systems for ultimate patient prediction have used.Results: The proposed system, based on the best features in the provided data base in the form of the combination and interaction, succeeded to achieve a 95.1% precision, of course due to comparing by other commonly used methods and its performance the proposed method have high precision.Conclusion: The results were significantly improved compared to previous studies. Also, in comparison with the results of physicians, it is indicative of good performance in predicting the accuracy of the time series of glucose concentration because the proposed system succeeded in predicting blood sugar levels for up to 48 hours.

Background: Improving self-care behaviors happened by self-efficacy which result in better quality of life. Current study aimed at assessing the perceived coping self-efficacy predictors among patients with type 2 diabetes referees to health centers affiliated to Tehran University of Medical Sciences.Methods: In this cross sectional study which was descriptive and analytical one, perceived coping self-efficacy and its effective factors assessed among 536 type 2 diabetic patients referee to Tehran University of medical Sciences using random sampling based on 11-likert scale questionnaire. This questionnaire included 11 items in demographic variables and 24 items in perceived coping self-efficacy. Collected data analyzed by SPSS version 23 using MANCOVA.Results: Study findings revealed that age (P=0.013), level of education (P<0.036), and HbA1c (P=0.004) had significant relation with total score of perceived coping self-efficacy. But, variables such as gender, occupation, disease duration, marital status, family history and history of chronic disease had no relation with scales of perceived coping self-efficacy.Conclusion: Planning theory based intervention programs to improve coping self-efficacy among diabetic patients in low socioeconomic status population and poor diabetes control is recommended.

Background: Overcoming barriers associated with diabetes is considered a logical infrastructure to empower diabetic patients in management of living with diabetes and identify factors which affect these barriers. This study aimed to determine the effect of an educational intervention based on the BASNEF model on barriers to awareness, lifestyle, adaptation, and support in living with diabetes in patients with type 2 diabetes and it's related factors.Methods: This was a quasi-experimental study which. Performed among 168 patients with type 2 diabetes referred to health centers of Beheshti University of Medical Sciences from August to September 2014. Before the educational intervention, questionnaires of life barriers and the BASNEF structures were completed. After pre-test, the patients were randomly allocated to the case and control groups based on randomizing four block design. Only in the intervention group patients received six education sessions of 45 to 60 minutes that fifth education session with their families, and related staff. The educational program was designed based on the BASNEF constructs (Knowledge, attitude, subjective norm, enabling factors and behavioral intention), and educational content was developed based on the barriers to living with diabetes (awareness, lifestyle, adaptation, and protection). Data analyzed Spss stafware version 20 utelized to data analysis using statistical tests such as independent sample t-test, paired t test, Wilcoxon, McNemar test, and Mann-Whitney U.Results: Our findings showed that there was a significant difference between a score received on components of barriers to of living with diabetes (awareness, lifestyle, adaptation, and protection) and variable of the BASNEF model (knowledge, attitude, subjective norm, enabling factors and behavioral intention) before and after the educational intervention the significant level was set less than 0.05 (P<0.05).Conclusion: Education in type 2 diabetic patients based on BASNEF, as a model for effective education, can lead to dimensions barriers reduction in (awareness, lifestyle, adaptation, and protection).

Background: The purpose of this study was to compare effects of three combined aerobic-resistance exercise training protocols with different intensities on metabolic control and Visfatin levels in men with type 2 diabetes.Methods: 43 male patients with type 2 diabetes were randomly divided into 4 groups (three combined aerobic-resistance exercise training groups 1, 2, 3 and control). Training groups performed combined aerobic-resistance exercises for 12weeks, 3 times a week with given intensities) group 1: resistance 50-60% one repetition maximum- aerobic 70-80%maximum heart rate, group 2: resistance 60-70% one repetition maximum- aerobic 60-70% maximum heart rate and group 3: resistance 70-80% one repetition maximum- aerobic 50-60% maximum heart rate). Blood sampling to determine the levels of Visfatin, insulin, HbA1c, fasting glucose before and after 12weeks, were conducted.Results: Visfatin levels and HbA1c in all training groups and fasting glucose in 2 combined training groups significantly decreased compared with control group (P<0.05). Vo2max was significantly increased in all training groups (P<0.05). No significant difference were observed between groups in body weight, Body mass index, fat mass, insulin levels and resistance insulin.Conclusion: 12 weeks of combined aerobic-resistance exercise training protocols with were executed intensities through decreasing Visfatin and HbA1c levels and improving aerobic capacity could be helpful in patient with type 2diabetes. In addition to the above benefits, combined exercise training protocols of with intensity of 60-70% maximum heart rate-intensity 60-70% repetition maximum due to reducing fasting blood glucose could give greater benefits to patients.