EFFECT OF 12 WEEK RESISTANCE TRAINING ON GENE EXPRESSIONS RAGE, ICAM, VCAM IN THE HEART OF DIABETIC RATS WITH STZ

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MOHAMMADI RASOUL; MATIN HOMAEE HASAN; AZERBAIYANI MOHAMMAD ALI; BAESI KAZEM

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Journal: Iranian Journal of Diabetes and Metabolism Year:2016 | Volume:16 | Issue:1 Page(s): 1-8

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Title

EFFECT OF 12 WEEK RESISTANCE TRAINING ON GENE EXPRESSIONS RAGE, ICAM, VCAM IN THE HEART OF DIABETIC RATS WITH STZ

Author(s)

MOHAMMADI RASOUL | MATIN HOMAEE HASAN | AZERBAIYANI MOHAMMAD ALI | BAESI KAZEM | Issue Writer Certificate

Keywords

RESISTANCE TRAININGQ1

RAGEQ2

ICAMQ1

VCAMQ1

Abstract

Background: Cardiomyopathy is a side effect caused by diabetes. Prolonged hyperglycemia gives rise to an increase in the expression of the receiver gene RAGE subsequently triggering pathogenesis cardiac signaling pathways in the heart of rats with type II diabetes. The present paper aims to examine how a 12 week RESISTANCE TRAINING on gene expressions RAGE, ICAM, VCAM in the heart of diabetic rats with STZ.Methods: 16 male Wistar rats with weight mean ranging from 200±20 g were randomly assigned to two groups of Resistance diabetes (n=8) and control diabetes (n=8) and were kept under lab circumstances. A 12 week RESISTANCE TRAINING was administered with the experimental group and 48 hours after the end of the last training session the rats were made unconscious and examined. Their hearts were, afterwards, cut out and the extent of gene expressions RAGE, ICAM, VCAM in the left ventricular heart was measured using Real time-PCR method.Results: The results indicated there was a significant difference between left ventricular heart of the Resistance diabetes and that of control diabetes in terms of gene expression RAGE, yet no significant difference was detected between the two groups in terms of gene expressions ICAM, VCAM.Conclusion: According to the results, in seems that RESISTANCE TRAININGs effectively reduce gene expressions RAGE and reduction pattern but non-significant in the Gene ICAM, VCAM in left ventricular heart of diabetic rats and therefore can be considered an effective way in reducing pathogenesis cardiac signaling pathways in the heart of rats with type II diabetes.

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APA: Copy

MOHAMMADI, RASOUL, MATIN HOMAEE, HASAN, AZERBAIYANI, MOHAMMAD ALI, & BAESI, KAZEM. (2016). EFFECT OF 12 WEEK RESISTANCE TRAINING ON GENE EXPRESSIONS RAGE, ICAM, VCAM IN THE HEART OF DIABETIC RATS WITH STZ. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 16(1 ), 1-8. SID. https://sid.ir/paper/53941/en

Vancouver: Copy

MOHAMMADI RASOUL, MATIN HOMAEE HASAN, AZERBAIYANI MOHAMMAD ALI, BAESI KAZEM. EFFECT OF 12 WEEK RESISTANCE TRAINING ON GENE EXPRESSIONS RAGE, ICAM, VCAM IN THE HEART OF DIABETIC RATS WITH STZ. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2016;16(1 ):1-8. Available from: https://sid.ir/paper/53941/en

IEEE: Copy

RASOUL MOHAMMADI, HASAN MATIN HOMAEE, MOHAMMAD ALI AZERBAIYANI, and KAZEM BAESI, “EFFECT OF 12 WEEK RESISTANCE TRAINING ON GENE EXPRESSIONS RAGE, ICAM, VCAM IN THE HEART OF DIABETIC RATS WITH STZ,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 16, no. 1 , pp. 1–8, 2016, [Online]. Available: https://sid.ir/paper/53941/en

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