With the aim of investigating relation between depression and bias judgment by general self-efficacy and self-focused attention, 446 high school student (263 girl and 183 boy) that were enrolled in second, third and fourth grade of high school were selected by means of cluster sampkings. These students were enrolled, in 3 field of study (mathematical, experimental sciences, human sciences), in public and private schools in east of Gilan in 2011-2012 academic year, these students completed the following questionaires the Children Depression Inventory (CDI Kovacs and Beck, 1997) the Probability/Outcome Negative Social Events Questionnaire (PCQ-C, Foa, Franklin, Perry and Her bert,1996) the Spotlight Attention Questionnaire (FAQ, Woody, Chambless, Glass, 1997) and the General Self- Efficacy Scale (GSE-10, Schwarz, 1992). Data were analyzed using the correlation coefficient and regression analysis. Findings from analysis showed that depression by general self-efficacy and self-focused attention has indirect effect over bias judgment. On the other hand depression had significant correlation with general self-efficacy and self-focused attention and also general self-efficacy and self-focused attention had a significant correlation with probability and outcome negative social events. Finally confirmed mediator pattern that means general self-efficacy and self-focused attention mediating role in relationship between depression and bias judgment. the results according to the previous research, discussed and analsyed.