The purpose of this study was testing the model of structural relationships between primary and secondary cognitive appraisals, optimism, coping strategies and subjective well-being among university students. 371 students (188 male and 183 female) completed the Stress Appraisal Measure (Rowley, Roesch, Jurica &Vaughn, 2005), the Life Orientation Test-Revised (Schier, Carver & Bridges, 1994), the Way of Coping Questionnaire-Revised (Folkman & Lazarus, 1985)), the Positive and Negative Affect Schedul (Watson, Clark & Tellegen) and the Satisfaction with Life Scale (Denier, Emmons, Larsen & Griffin). The result of structural equation modeling showed that hypothesized models had an acceptable fit to the data. In mediating model of task-oriented coping strategies, resources and challenge with optimism and task-oriented a significant positive relationship and the results indicated a significant negative relationship between threat with optimism and task-oriented coping. In addition the results showed significant positive relationship between optimism and task-oriented with well-being and between task-oriented and well-being. In contrast, mediating model of tension reduction, resources and challenge with tension reduction showed a non-significant negative relationship and the results indicated a non-significant positive relationship with tension reduction. Results also indicated that the relationship between primary and secondary appraisals with subjective well-being by optimism and task- oriented is mediated partially. In mediating models of adaptive and non-adaptive coping strategies, Models predictors accounted for 76% and 80% of the variance in subjective well-being, respectively.