Background & Objectives: There is growing evidence that the relationship between coping ways with stress and Coronary Heart Disease. Therefore, the aim of this study was to examine the relation between coping ways with stress and IL-6 immunologic biomarker in Coronary Heart Disease (CHD) when faced with a stressful event.Materials & Methods: Statistical community was all CHD patients referred to Shahid Rajaie Heart Hospital in Tehran in 2012. 44 patients with CHD were chosen from eligible patients. In this study, coping ways questionnaire of Lazarus and Folkman, human IL-6 kit and Stroop color test software were used. For statistical analysis of survey data, statistical methods of mean, standard deviation, Pearson correlation and multiple regression analysis were utilized. Computer software for data processing in this study was SPSS-17.Results: The results indicated that, when the patients face with a stressful event, there are significant positive correlation (P<0.001, R=0.635) between emotional focused coping ways with IL-6 immunologic biomarker and significant negative correlation (P<0.001, R=-0.698) between problem focused coping ways and IL-6 immunologic biomarker. Also, when the patients face with a stressful event, from 8 coping ways with stress confidently of 0.99, only positive re-evaluation has significant predict for IL-6 immunologic biomarker (P<0.001).Conclusion: Results showed that, when the patients face with a stressful event, the increased use of emotional focused coping ways leads to increase in the level of biomarker IL-6, and increased use of problem focused coping ways leads to decrease in level of biomarker IL-6.