The Effect of High and Low-Intensity Interval Training on TRF1 and TRF2 Gene Expression in Slow and Fast-Twitch Skeletal Muscles of C57BL/6 Mice: An Experimental Study

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Khodadoost Mostafa; SHAKERYAN SAEED; ARJMAND SAREH; NIKBAKHT MASOOD

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Journal Paper

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Journal: Journal of Rafsanjan University of Medical Sciences Year:2022 | Volume:21 | Issue:1 Page(s): 49-70

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Information Journal Paper

Title

The Effect of High and Low-Intensity Interval Training on TRF1 and TRF2 Gene Expression in Slow and Fast-Twitch Skeletal Muscles of C57BL/6 Mice: An Experimental Study

Author(s)

Khodadoost Mostafa | SHAKERYAN SAEED | ARJMAND SAREH | NIKBAKHT MASOOD | Issue Writer Certificate

Keywords

Interval training

ST and FT skeletal muscles

TRF1

TRF2

Abstract

Background and Objectives: The process of chronic diseases and aging is associated with reduced telomere length. The aim of this study was to investigate the effect of high-intensity Interval training (HIIT) and low-intensity Interval training (LIIT) on telomere repeat binding factor 1 and 2 (TRF1 and TRF2) in Soleus (SOL) muscle as a slow-twitch (ST) and Extensor Digitorum Longus (EDL) muscle as a fast-twitch (FT) of mice skeletal muscle. Materials and Methods: In this experimental study, the subjects were C57BL/6 mice (n=24) that were randomly divided into four groups of 6 mice: 1-Base control, 2-control, 3-high-intensity Interval training (HIIT), and 4-lowintensity Interval training (LIIT). The exercise included 5 days a week for 8 weeks. The gene expression of muscle tissues was measured using RT-PCR. The data were evaluated using two-way ANOVA with Tukey’, s post hoc test. Results: By comparing ST and FT muscles (p=0. 791) and HIIT and LIIT groups (p=0. 164) and also the interaction between muscle type and training intensity (p=0. 929), there was no significant difference in the expression of TRF1 gene. There was no significant interaction between TRF2 gene expression in ST and FT muscles at different intensities (p=0. 868). But the results of Tukey’, s post hoc test showed that in terms of TRF2 gene expression, HIIT (p=0. 031) and LIIT (p=0. 035) groups showed more increase compared to the control group. Conclusion: HIIT and LIIT similarly improved the telomere system in skeletal muscle of both muscle types, and this system was more affected by telomere elongation effect of TRF2.

Cites

An Experimental Study of the Effect of Six Weeks of Aerobic Exercise along with Q10 Supplementation on TRF1 and TRF2 Gene Expression in Heart Tissue of Aged Wistar Male Rats

References

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APA: Copy

Khodadoost, Mostafa, SHAKERYAN, SAEED, ARJMAND, SAREH, & NIKBAKHT, MASOOD. (2022). The Effect of High and Low-Intensity Interval Training on TRF1 and TRF2 Gene Expression in Slow and Fast-Twitch Skeletal Muscles of C57BL/6 Mice: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, 21(1 ), 49-70. SID. https://sid.ir/paper/1001606/en

Vancouver: Copy

Khodadoost Mostafa, SHAKERYAN SAEED, ARJMAND SAREH, NIKBAKHT MASOOD. The Effect of High and Low-Intensity Interval Training on TRF1 and TRF2 Gene Expression in Slow and Fast-Twitch Skeletal Muscles of C57BL/6 Mice: An Experimental Study. JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES[Internet]. 2022;21(1 ):49-70. Available from: https://sid.ir/paper/1001606/en

IEEE: Copy

Mostafa Khodadoost, SAEED SHAKERYAN, SAREH ARJMAND, and MASOOD NIKBAKHT, “The Effect of High and Low-Intensity Interval Training on TRF1 and TRF2 Gene Expression in Slow and Fast-Twitch Skeletal Muscles of C57BL/6 Mice: An Experimental Study,” JOURNAL OF RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, vol. 21, no. 1 , pp. 49–70, 2022, [Online]. Available: https://sid.ir/paper/1001606/en

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