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Information Journal Paper

Title

Effect of 4 weeks of High-Intensity Interval Training on P53 and Caspase-3 Proteins Content in the Heart Muscle Tissue of Rats with Type 1 Diabetes

Pages

  4255-4267

Abstract

 Introduction: Type 1 Diabetes can lead to muscle Apoptosis and a defect in the structure of the heart tissue. One of the main pathways of Apoptosis is the pathway activated by the P53 and Caspase-3 proteins. Therefore, the aim of this study was to investigate the effect of 4 weeks of High intensity interval training on the content of P53 and Caspase-3 proteins in heart muscle tissue of Sprague-Dawley rats with type 1 diabetic rats. Methods: In this experimental study, twelve 2-month-old Sprague-Dawley male rats with mean weight of 300±, 20 gr were selected and after induction of diabetes through streptozotocin solution, randomly divided into 2 groups: experimental (n= 6) and control (n= 6). The training program consisted of 5 stages of 4-minute with an intensity of 85 to 95% of the maximum speed and 3-minute active rest periods with an intensity of 50 to 60% of the maximum speed. Proteins were measured by Western-Blot in vitro. SPSS software version 16 and independent t-test were used to analyze the data. Results: High intensity interval training resulted in a significant reduction in the P53 protein content of the training group compared to the control group (P=0. 003). However, there was no significant change in the content of Caspase-3 in the activated form (P=0. 71) and the initial form (P=0. 15) in the training group compared to the control group. Conclusion: High intensity interval training, by reducing the content of the P53 protein and preventing the activation of the caspase-3 protein, may have inactivated the Apoptosis pathway of these two proteins in heart cells in type 1 diabetic subjects.

Cites

References

Cite

APA: Copy

JOKAR, MASOUD, & SHERAFATI MOGHADAM, MOHAMMAD. (2022). Effect of 4 weeks of High-Intensity Interval Training on P53 and Caspase-3 Proteins Content in the Heart Muscle Tissue of Rats with Type 1 Diabetes. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 29(11 ), 4255-4267. SID. https://sid.ir/paper/1016590/en

Vancouver: Copy

JOKAR MASOUD, SHERAFATI MOGHADAM MOHAMMAD. Effect of 4 weeks of High-Intensity Interval Training on P53 and Caspase-3 Proteins Content in the Heart Muscle Tissue of Rats with Type 1 Diabetes. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2022;29(11 ):4255-4267. Available from: https://sid.ir/paper/1016590/en

IEEE: Copy

MASOUD JOKAR, and MOHAMMAD SHERAFATI MOGHADAM, “Effect of 4 weeks of High-Intensity Interval Training on P53 and Caspase-3 Proteins Content in the Heart Muscle Tissue of Rats with Type 1 Diabetes,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 11 , pp. 4255–4267, 2022, [Online]. Available: https://sid.ir/paper/1016590/en

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