The effect of 8 weeks endurance exercise on the content of total and phosphorylated AKT1, mTOR, P70S6K1 and 4E-BP1 in skeletal muscle FHL of rats with type 2 diabetes

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Shadmehri Saeedeh; SHERAFATI MOGHADAM MOHAMMAD; DARYANOOSH FARHAD; JAHANI GOLBAR SHIVA; TANIDEH NADER

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:26 | Issue:12 Page(s): 1063-1074

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Title

The effect of 8 weeks endurance exercise on the content of total and phosphorylated AKT1, mTOR, P70S6K1 and 4E-BP1 in skeletal muscle FHL of rats with type 2 diabetes

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Keywords

Endurance ExerciseQ1

Skeletal MuscleQ2

Type 2 DiabeteQ2

Abstract

Introduction: The mTOR pathway in Skeletal Muscle plays a very important role in the protein synthesis process, which plays a very important role in proteins. The role of Endurance Exercise has not yet been studied in this important pathway in protein synthesis in people with Type 2 Diabetes. The purpose of the present study was to investigate the effect of 8 weeks endurance training on the content of total and phosphorylated AKT1, mTOR, P70S6K1 and 4E-BP1 in Skeletal Muscle FHL of rats with Type 2 Diabetes. Methods: In this experimental study, 16 Sprague-Dawely male rats with average weight of 270± 20 were selected and randomly divided into two groups: control (n=8) and endurance training (n=8). The training group exercised according to the training program 4 days a week for 8 weeks. While the control group had no training program. T-test and SPSS V-19 were used to analyze the data. Results: There was not observed any significant difference in the content of total (P=0. 58) and phosphorylated (P=0. 33) AKT1, total (P=0. 47) and phosphorylated (P=0. 78) mTOR, total (P=0. 24) and phosphorylated (P=0. 12) P70S6K1 and total (P=0. 45) and phosphorylated (P=0. 48) 4E-BP1 proteins in the endurance training group compared to the control group. Conclusion: Endurance training for 8 weeks could not increase the total and phosphorylated content proteins of the present study; therefore, it cannot lead to protein synthesis or muscle hypertrophy through mTORC1 pathway.

Cites

THE EFFECT OF ENDURANCE TRAINING ON PROTEIN KINASE-B AND MECHANICAL TARGET OF RAPAMYCIN IN THE LEFT VENTRICLE OF THE HEART OF DIABETIC RATS INDUCED BY STREPTOZOTOCIN AND NICOTINAMIDE

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APA: Copy

Shadmehri, Saeedeh, SHERAFATI MOGHADAM, MOHAMMAD, DARYANOOSH, FARHAD, JAHANI GOLBAR, SHIVA, & TANIDEH, NADER. (2019). The effect of 8 weeks endurance exercise on the content of total and phosphorylated AKT1, mTOR, P70S6K1 and 4E-BP1 in skeletal muscle FHL of rats with type 2 diabetes. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(12 ), 1063-1074. SID. https://sid.ir/paper/366421/en

Vancouver: Copy

Shadmehri Saeedeh, SHERAFATI MOGHADAM MOHAMMAD, DARYANOOSH FARHAD, JAHANI GOLBAR SHIVA, TANIDEH NADER. The effect of 8 weeks endurance exercise on the content of total and phosphorylated AKT1, mTOR, P70S6K1 and 4E-BP1 in skeletal muscle FHL of rats with type 2 diabetes. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(12 ):1063-1074. Available from: https://sid.ir/paper/366421/en

IEEE: Copy

Saeedeh Shadmehri, MOHAMMAD SHERAFATI MOGHADAM, FARHAD DARYANOOSH, SHIVA JAHANI GOLBAR, and NADER TANIDEH, “The effect of 8 weeks endurance exercise on the content of total and phosphorylated AKT1, mTOR, P70S6K1 and 4E-BP1 in skeletal muscle FHL of rats with type 2 diabetes,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 12 , pp. 1063–1074, 2019, [Online]. Available: https://sid.ir/paper/366421/en

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