A COMPARATIVE STUDY OF SATURATED, TRANS AND CIS FATTY ACIDS MEASURED IN SERUM AND ADIPOSE TISSUE BETWEEN PATIENTS WITH TYPE 2 DIABETES AND NORMAL SUBJECTS

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FIROUZRAI M.; GHAHRAMANPOUR F.; KARANI M.; HEYDARI I.

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Journal: Razi Journal of Medical Sciences Year:2007 | Volume:14 | Issue:54 Page(s): 119-128

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Information Journal Paper

Title

A COMPARATIVE STUDY OF SATURATED, TRANS AND CIS FATTY ACIDS MEASURED IN SERUM AND ADIPOSE TISSUE BETWEEN PATIENTS WITH TYPE 2 DIABETES AND NORMAL SUBJECTS

Author(s)

FIROUZRAI M. | GHAHRAMANPOUR F. | KARANI M. | HEYDARI I. | Issue Writer Certificate

Keywords

TYPE 2 DIABETESQ2

FATTY ACIDSQ2

ADIPOSE TISSUEQ2

GAS CHROMATOGRAPHYQ2

Abstract

Background & Aim: Diabetes is a heterogenous disease which results from complex reactions among heredity, nutrition and lifestyle. Some studies have shown that a high intake of saturated FATTY ACIDS (SFA) increases the risk of TYPE 2 DIABETES, while polyunsaturated FATTY ACIDS (PUFA) decrease diabetes incidence by increasing insulin affinity to the receptors. In this study, serum FATTY ACIDS and ADIPOSE TISSUE composition as a long-term biomarker for FATTY ACIDS intake are determined, and their correlation with TYPE 2 DIABETES is investigated.Patients & Method: This was a cross-sectional study in which the healthy and the patient groups were compared. The fatty acid composition of fasting serum and ADIPOSE TISSUE was studied in 98 patients with TYPE 2 DIABETES and 76 healthy control subjects using gas-liquid chromatography. The serum lipids were measured by autoanalyzer. The means of variables were compared by using Students’ t-test.Results: The percentages of palmitic acid and positional isomer of oleic acid (11c-18:1) in ADIPOSE TISSUE of the patients were higher than the control group(P=0.01, P=0.02 respectively). The percentages of palmitic acid, total saturated and monounsaturated FATTY ACIDS in the serum of the patients were higher than the control group too(P=0.001, P=0.006, P=0.02 respectively). Linoleic acid and polyunsaturated FATTY ACIDS were lower than the control group, however (P=0.02, P=0.02 respectively). Mean concentration of triglyceride in the patients was higher than the control group (t=-6.7, P=0.001). There was a negative correlation between serum PUFAs and cholesterol to HDL ratio in serum and a positive correlation between serum PUFAs and TG in serum. Also, PUFAs in serum had a negative correlation with TG in serum. Conclusion: Large amounts of palmitic acid and 11c-18:1 in ADIPOSE TISSUE may increase the risk of TYPE 2 DIABETES and it seems that patients with TYPE 2 DIABETES can have proper control over lipid parameters by having a higher intake of polyunsaturated FATTY ACIDS than saturated FATTY ACIDS.

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APA: Copy

FIROUZRAI, M., GHAHRAMANPOUR, F., KARANI, M., & HEYDARI, I.. (2007). A COMPARATIVE STUDY OF SATURATED, TRANS AND CIS FATTY ACIDS MEASURED IN SERUM AND ADIPOSE TISSUE BETWEEN PATIENTS WITH TYPE 2 DIABETES AND NORMAL SUBJECTS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 14(54), 119-128. SID. https://sid.ir/paper/10194/en

Vancouver: Copy

FIROUZRAI M., GHAHRAMANPOUR F., KARANI M., HEYDARI I.. A COMPARATIVE STUDY OF SATURATED, TRANS AND CIS FATTY ACIDS MEASURED IN SERUM AND ADIPOSE TISSUE BETWEEN PATIENTS WITH TYPE 2 DIABETES AND NORMAL SUBJECTS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2007;14(54):119-128. Available from: https://sid.ir/paper/10194/en

IEEE: Copy

M. FIROUZRAI, F. GHAHRAMANPOUR, M. KARANI, and I. HEYDARI, “A COMPARATIVE STUDY OF SATURATED, TRANS AND CIS FATTY ACIDS MEASURED IN SERUM AND ADIPOSE TISSUE BETWEEN PATIENTS WITH TYPE 2 DIABETES AND NORMAL SUBJECTS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 14, no. 54, pp. 119–128, 2007, [Online]. Available: https://sid.ir/paper/10194/en

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