THE EFFECT OF INTERFERON β-1B ON THE NUMBER OF PLAQUES AND DIFFERENT SITES OF BRAIN MRI LESIONS IN RELAPSING-REMITTING ULTIPLE SCLEROSIS (RRMS)

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FERESHTEHNEJAD S.M.; MOTAMED M.R.; NAJIMI N.; SHAHBEYGI S.; JAVDANI MARYAM

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Journal: Current Journal of Neurology Year:2009 | Volume:8 | Issue:26-27 Page(s): 577-587

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Title

THE EFFECT OF INTERFERON β-1B ON THE NUMBER OF PLAQUES AND DIFFERENT SITES OF BRAIN MRI LESIONS IN RELAPSING-REMITTING ULTIPLE SCLEROSIS (RRMS)

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Keywords

REMITTING-RELAPSING MULTIPLE SCLEROSIS (RRMS)Q1

INTERFERON β-1BQ1

MAGNETIC RESONANCE IMAGING (MRI)Q1

EXPANDED DISABILITY STATUS SCALE (EDSS)Q1

RELAPSEQ1

DISEASE-MODIFYING TREATMENTQ1

Abstract

Introduction: The aim of our study was to evaluate the effect of DISEASE-MODIFYING TREATMENT with interferon (IFN) beta-1b (Betaferon) on RELAPSEs, progression of disability and brain MRI findings in patients with relapsing-remitting multiple sclerosis (RRMS).Patients and Methods: This cohort study was conducted on 41 patients who had RRMS determined using McDonald criteria. They were evaluated during a 24-month study period from January 2004 to January 2006. Patients were assigned in two groups: 21 patients under disease-modifying therapy with IFN beta-1b (Betaferon) 250 mcg subcutaneously every other day (group A) and 20 patients without DISEASE-MODIFYING TREATMENT (group B). Neurological and clinical assessments were done at baseline, 12th, 18th and 24th month of follow-up. For this purpose, number of new attacks, changes of brain MRI findings and Kurtzke Expanded Disability Status Scale (EDSS) were evaluated.Results: Patients in group A represent lesser number of attack (0.76, SD=0.70 vs. 2.05, SD=0.76; P<0.001), more reduction in EDSS (2.09, SD=0.77 vs. 0.12, SD=0.65; P<0.001) and number of ventricular plaques in brain MRI (3.29, SD=1.35 vs. 0.15, SD=0.87; P<0.001) in comparison with group B. The course of EDSS changes was significant in both groups A and B during the study period (PA<0.001 and PB=0.019). But, only patients in group A expressed improvement of brain lesions in MRIs, such as juxta-cortical (P<0.001), cerebellar (P=0.008), brain-stem (P=0.004), spinal-cord (P=0.008) and corpus callosum (P=0.016).Conclusions: Our result demonstrated DISEASE-MODIFYING TREATMENT for RRMS patients may lead to beneficial results. And also IFN beta-1b significantly delayed progression to disability, reduced incidence of new RELAPSEs and improved brain lesions especially juxta-cortical and brain-stem plaques.

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APA: Copy

FERESHTEHNEJAD, S.M., MOTAMED, M.R., NAJIMI, N., SHAHBEYGI, S., & JAVDANI, MARYAM. (2009). THE EFFECT OF INTERFERON β-1B ON THE NUMBER OF PLAQUES AND DIFFERENT SITES OF BRAIN MRI LESIONS IN RELAPSING-REMITTING ULTIPLE SCLEROSIS (RRMS). CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), 8(26-27), 577-587. SID. https://sid.ir/paper/102820/en

Vancouver: Copy

FERESHTEHNEJAD S.M., MOTAMED M.R., NAJIMI N., SHAHBEYGI S., JAVDANI MARYAM. THE EFFECT OF INTERFERON β-1B ON THE NUMBER OF PLAQUES AND DIFFERENT SITES OF BRAIN MRI LESIONS IN RELAPSING-REMITTING ULTIPLE SCLEROSIS (RRMS). CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY)[Internet]. 2009;8(26-27):577-587. Available from: https://sid.ir/paper/102820/en

IEEE: Copy

S.M. FERESHTEHNEJAD, M.R. MOTAMED, N. NAJIMI, S. SHAHBEYGI, and MARYAM JAVDANI, “THE EFFECT OF INTERFERON β-1B ON THE NUMBER OF PLAQUES AND DIFFERENT SITES OF BRAIN MRI LESIONS IN RELAPSING-REMITTING ULTIPLE SCLEROSIS (RRMS),” CURRENT JOURNAL OF NEUROLOGY (IRANIAN JOURNAL OF NEUROLOGY), vol. 8, no. 26-27, pp. 577–587, 2009, [Online]. Available: https://sid.ir/paper/102820/en

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