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Information Journal Paper

Title

THE INTERACTION BETWEEN CETP TAQ1B POLYMORPHISM AND DIETARY FAT INTAKE ON HDL-C ACCORDING TO LIPID PROFILE STATUS IN TYPE 2 DIABETES MELLITUS PATIENTS

Pages

  98-108

Abstract

 Background: Dyslipidemia is a major problem in TYPE 2 DIABETES mellitus patients (T2DM) causing atherosclerosis diseases. We investigated the relationship between CETP TAQ1B POLYMORPHISM and HDL-C concentrations considering DIETARY FAT INTAKE in Tehranian dyslipidemic and normolipidemic T2DM patients.Methods: In the present cross-sectional study 184 T2DM patients were investigated. We used FFQ questionnaire, anthropometric measurements and biochemical tests. PCR-RFLP was used to determine polymorphism. We performed Chi-square and ANOVA and ANCOVA for statistical analysis.Results: The frequency of B1B1 genotype was significantly different according to patients’ lipid profile status (p=0.014). There was no significant relationship between genotype and HDL-C concentrations. The interaction between CETP TAQ1B POLYMORPHISM and total fat intake was significant in normolipidemic patients (Pinteraction=0.028). There were no such a relationships in dyslipidemic patients. In addition, patients with B2B2 genotype and low total fat intake had significantly higher HDL-C concentrations in comparison with B1B1 genotype (p=0.030).Conclusion: Patients with B1B1 genotype were more likely to be dyslipidemic. The relationship between CETP TAQ1B POLYMORPHISM and HDL-C concentrations was affected by dietary total fat intake in normolipidemic T2DM patients.

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    APA: Copy

    Kalantar, Zahra, MAHMOODI, MARYAM, SOTOUDEH, GITY, MANSOORI, ANAHITA, JALALI, MAHMOUD, ESHRAGHIAN, MOHAMADREZA, & KOOHDANI, FARIBA. (2016). THE INTERACTION BETWEEN CETP TAQ1B POLYMORPHISM AND DIETARY FAT INTAKE ON HDL-C ACCORDING TO LIPID PROFILE STATUS IN TYPE 2 DIABETES MELLITUS PATIENTS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 23(149), 98-108. SID. https://sid.ir/paper/10324/en

    Vancouver: Copy

    Kalantar Zahra, MAHMOODI MARYAM, SOTOUDEH GITY, MANSOORI ANAHITA, JALALI MAHMOUD, ESHRAGHIAN MOHAMADREZA, KOOHDANI FARIBA. THE INTERACTION BETWEEN CETP TAQ1B POLYMORPHISM AND DIETARY FAT INTAKE ON HDL-C ACCORDING TO LIPID PROFILE STATUS IN TYPE 2 DIABETES MELLITUS PATIENTS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2016;23(149):98-108. Available from: https://sid.ir/paper/10324/en

    IEEE: Copy

    Zahra Kalantar, MARYAM MAHMOODI, GITY SOTOUDEH, ANAHITA MANSOORI, MAHMOUD JALALI, MOHAMADREZA ESHRAGHIAN, and FARIBA KOOHDANI, “THE INTERACTION BETWEEN CETP TAQ1B POLYMORPHISM AND DIETARY FAT INTAKE ON HDL-C ACCORDING TO LIPID PROFILE STATUS IN TYPE 2 DIABETES MELLITUS PATIENTS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 23, no. 149, pp. 98–108, 2016, [Online]. Available: https://sid.ir/paper/10324/en

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