A COMPARATIVE STUDY OF THE EFFECT OF PARACETAMOL AND REMIFENTANIL ON THE DEPTH OF BIS-GUIDED ANESTHESIA IN ENDOSCOPIC SINUS SURGERY

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HASANI V.A.; FARHADI M.; MIRSADRAEE A.

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Journal: Razi Journal of Medical Sciences Year:2007 | Volume:13 | Issue:53 Page(s): 67-72

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Title

A COMPARATIVE STUDY OF THE EFFECT OF PARACETAMOL AND REMIFENTANIL ON THE DEPTH OF BIS-GUIDED ANESTHESIA IN ENDOSCOPIC SINUS SURGERY

Author(s)

HASANI V.A. | FARHADI M. | MIRSADRAEE A. | Issue Writer Certificate

Keywords

PARACETAMOLQ2

REMIFENTANILQ3

ENDOSCOPIC SINUS SURGERYQ3

Abstract

Background & Aim: PARACETAMOL is a non-opioid and non-NSAID (non non-steroidal anti-inflammatory drug) analgesic with central function. Analgesic effect of PARACETAMOL is similar to opioids and NSAIDs but different from them in terms of side effects. REMIFENTANIL is a short-acting opioid. In our study, we assess the effect of these two drugs on the depth of anesthesia using BIS monitoring. BIS (Bispectral) index is a complex EEG (Electroencephalograph) parameter. Bispectral index values of 0 represent an isoelectric EEG, where values of 100 represent awareness.Patients & Method: This study was done on 100 ASA-1 (American Society of Anesthesiologists) patients who were candidates for ENDOSCOPIC SINUS SURGERY. Patients who were out of the age range of 15-45 years were excluded. Then the patients were randomly divided into two groups of 50. The first group included patients using PARACETAMOL and the other group used REMIFENTANIL. Both groups received 1 μg/kg of fentanil as premedication. Induction of anesthesia in the first group was started by using propofol 2.5mg/kg and then cysatracurium 0.15 mg/kg. Propofol 100 μg/kg/min+N2O 50%, O2 50% (equal minute volume)+PARACETAMOL 1 gr/Q4h were administered for maintenance. In the other group the induction was similar to the first group, but for maintenance propofol 100 μg/kg/min+N2O 50%, O2 50%(equal minute volume)+remifentanil 1 μg/kg/min were administered. For each group, depth of anesthesia was measured during laryngoscopy, intubation and incision. Blood pressure and heart rate were recorded on collecting data sheets too.Results: Data was analyzed using independent sample t-test and PV<0.05 was statistically significant. The analysis of data showed no significant difference between the two groups (PV>0.05). As a result, there is no difference between the effect of PARACETAMOL and REMIFENTANIL on the depth of anesthesia.Conclusion: These findings suggest that infusion of PARACETAMOL replace REMIFENTANIL in order to observe hemodynamic stability during the surgery.

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APA: Copy

HASANI, V.A., FARHADI, M., & MIRSADRAEE, A.. (2007). A COMPARATIVE STUDY OF THE EFFECT OF PARACETAMOL AND REMIFENTANIL ON THE DEPTH OF BIS-GUIDED ANESTHESIA IN ENDOSCOPIC SINUS SURGERY. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 13(53), 67-72. SID. https://sid.ir/paper/10358/en

Vancouver: Copy

HASANI V.A., FARHADI M., MIRSADRAEE A.. A COMPARATIVE STUDY OF THE EFFECT OF PARACETAMOL AND REMIFENTANIL ON THE DEPTH OF BIS-GUIDED ANESTHESIA IN ENDOSCOPIC SINUS SURGERY. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2007;13(53):67-72. Available from: https://sid.ir/paper/10358/en

IEEE: Copy

V.A. HASANI, M. FARHADI, and A. MIRSADRAEE, “A COMPARATIVE STUDY OF THE EFFECT OF PARACETAMOL AND REMIFENTANIL ON THE DEPTH OF BIS-GUIDED ANESTHESIA IN ENDOSCOPIC SINUS SURGERY,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 13, no. 53, pp. 67–72, 2007, [Online]. Available: https://sid.ir/paper/10358/en

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