EVALUATION OF THE USE OF CYTOKERATIN STAINING TECHNIQUE IN THE DIAGNOSIS OF MICROMETASTASIS TO AXILLARY LYMPH NODES IN PATIENTS WITH BREAST CANCER

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BEHDADIPOUR Z.A.A.; MOKHTARI M.; RAJABI P.; SABERI M.

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Journal: JOURNAL OF MEDICAL RESEARCH (JMR) Year:2004 | Volume:2 | Issue:2 Page(s): 18-24

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Title

EVALUATION OF THE USE OF CYTOKERATIN STAINING TECHNIQUE IN THE DIAGNOSIS OF MICROMETASTASIS TO AXILLARY LYMPH NODES IN PATIENTS WITH BREAST CANCER

Author(s)

BEHDADIPOUR Z.A.A. | MOKHTARI M. | RAJABI P. | SABERI M. | Issue Writer Certificate

Keywords

BREAST CANCERQ2

MICROMETASTASISQ4

LYMPH NODEQ4

IMMUNOHISTOCHEMISTRYQ4

CYTOKERATIN STAININGBQ4

Abstract

Background: BREAST CANCER is the most common cancer in women. Involvement of LYMPH NODEs is the most important factor in the prognosis and treatment of BREAST CANCER. Usual methods like hematoxylin-eosin staining for diagnosis of micrometastases are not precise, therefore other techniques that can diagnose MICROMETASTASIS, even in the early stages, is very useful. So, in this study we used intracytoplasmic antigens and an immunohistochemical method (cytokeratin staining) to detect metastatic cells in axillary LYMPH NODEs. Patients and Methods: In a cross- sectional study, 82 women with BREAST CANCER who were referred to Alzahra Hospital in Isfahan during 2001-2003 were selected using simple sampling method. The sections were prepared from the samples and hematoxylin-eosin and immunohistochemical staining methods were done and the sections were studied by light microscopy. The results were analysed using Chi square (X2) and Fisher’s exact test and a pvalue less than 0.05 was considered as significant. Results: Using hematoxylin-eosin and cytokeratin staining methods, it was shown that the relative frequency of micrometastases were 15.85% and 46.34%, respectively. Conclusion: In order to identify micrometastatic cells, the cytokeratin staining method is better than the usual hematoxylin-eosin method. Up to now, many studies have been done showing that there is a significant difference between the two methods. In this study similar results were obtained. Therefore, it can be concluded that cytokeratin staining method can help in the diagnosis of BREAST CANCER more accurately. This, in turn, will help in the treatment strategies that are adopted and can be important in the prognosis of the disease.

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APA: Copy

BEHDADIPOUR, Z.A.A., MOKHTARI, M., RAJABI, P., & SABERI, M.. (2004). EVALUATION OF THE USE OF CYTOKERATIN STAINING TECHNIQUE IN THE DIAGNOSIS OF MICROMETASTASIS TO AXILLARY LYMPH NODES IN PATIENTS WITH BREAST CANCER. JOURNAL OF MEDICAL RESEARCH (JMR), 2(2), 18-24. SID. https://sid.ir/paper/105795/en

Vancouver: Copy

BEHDADIPOUR Z.A.A., MOKHTARI M., RAJABI P., SABERI M.. EVALUATION OF THE USE OF CYTOKERATIN STAINING TECHNIQUE IN THE DIAGNOSIS OF MICROMETASTASIS TO AXILLARY LYMPH NODES IN PATIENTS WITH BREAST CANCER. JOURNAL OF MEDICAL RESEARCH (JMR)[Internet]. 2004;2(2):18-24. Available from: https://sid.ir/paper/105795/en

IEEE: Copy

Z.A.A. BEHDADIPOUR, M. MOKHTARI, P. RAJABI, and M. SABERI, “EVALUATION OF THE USE OF CYTOKERATIN STAINING TECHNIQUE IN THE DIAGNOSIS OF MICROMETASTASIS TO AXILLARY LYMPH NODES IN PATIENTS WITH BREAST CANCER,” JOURNAL OF MEDICAL RESEARCH (JMR), vol. 2, no. 2, pp. 18–24, 2004, [Online]. Available: https://sid.ir/paper/105795/en

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