Cancer virotherapy: Targeting cancer cells by microRNA mechanism for selective replication of oncolytic viruses in these cells

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KAKAVANDI Ehsan; SHAYESTEHPOUR MOHAMMAD; MOGHIM SHARAREH

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Journal Paper

Paper Information

Journal: Koomesh Year:2022 | Volume:24 | Issue:3 (89) Page(s): 288-299

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Title

Cancer virotherapy: Targeting cancer cells by microRNA mechanism for selective replication of oncolytic viruses in these cells

Author(s)

KAKAVANDI Ehsan | SHAYESTEHPOUR MOHAMMAD | MOGHIM SHARAREH | Issue Writer Certificate

Keywords

Oncolytic Viruses

Neoplasms

MicroRNA

Abstract

Cancer, as one of the most serious public health problems, is the second-leading cause of death in the world after cardiovascular disease. The number of patients and the resulting mortality are increasing worldwide,therefore, early diagnosis, prevention, and effective treatment of cancer are very important. Current treatments such as chemotherapy and radiation therapy are often non-selective and have side effects. The use of Oncolytic Viruses (viral therapy) is a new approach to treating cancer. One problem with viral therapy is the lack of selective replication for the virus in cancer cells, meaning that the virus replicates in normal cells. In recent years, various methods have been used to inhibit virus replication in healthy cells and to make selective replication in tumors. Correspondingly, MiRNA targeting is the newest method. The present review article describes the different aspects of making selectivity for replication of Oncolytic Viruses by the miRNA targeting mechanism.

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APA: Copy

KAKAVANDI, Ehsan, SHAYESTEHPOUR, MOHAMMAD, & MOGHIM, SHARAREH. (2022). Cancer virotherapy: Targeting cancer cells by microRNA mechanism for selective replication of oncolytic viruses in these cells. KOOMESH, 24(3 (89) ), 288-299. SID. https://sid.ir/paper/1059113/en

Vancouver: Copy

KAKAVANDI Ehsan, SHAYESTEHPOUR MOHAMMAD, MOGHIM SHARAREH. Cancer virotherapy: Targeting cancer cells by microRNA mechanism for selective replication of oncolytic viruses in these cells. KOOMESH[Internet]. 2022;24(3 (89) ):288-299. Available from: https://sid.ir/paper/1059113/en

IEEE: Copy

Ehsan KAKAVANDI, MOHAMMAD SHAYESTEHPOUR, and SHARAREH MOGHIM, “Cancer virotherapy: Targeting cancer cells by microRNA mechanism for selective replication of oncolytic viruses in these cells,” KOOMESH, vol. 24, no. 3 (89) , pp. 288–299, 2022, [Online]. Available: https://sid.ir/paper/1059113/en

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