مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

Human Olfactory Ecto-mesenchymal Stem Cells Displaying Schwann-cell-like Phenotypes and Promoting Neurite Outgrowth in Vitro

Pages

  31-42

Abstract

 Introduction: Strategies of Schwann cell (SC) transplantation for regeneration of peripheral nerve injury involve many limitations. Stem cells can be used as alternative cell source for differentiation into Schwann cells. Given the high potential of neural crest-derived stem cells for the generation of multiple cell lineages, in this research, we considered whether olfactory ectomesenchymal stem cells (OE-MSCs) derived from neural crest can spontaneously differentiate into SC lineage Methods: OE-MSCs were isolated from human nasal mucosa and characterized by the mesenchymal and neural crest markers. The cells were cultured in glial growth factors-free medium and further investigated in terms of the phenotypic and functional properties. Results: Immunocytochemical staining and real-time PCR analysis indicated that the cultured OE-MSCs expressed SCs markers, SOX10, p75, S100, GFAP and MBP, differentiation indicative. It was found that the cells could secrete neurotrophic factors, including brainderived neurotrophic factor (BDNF) and nerve growth factor (NGF). Furthermore, after cocultured with PC12, the mean neurite length was enhanced by OE-MSCs. Conclusion: The findings indicated that OE-MSCs could be differentiated spontaneously into SC-like phenotypes, suggesting their applications for transplantation in peripheral nerve injuries.

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    APA: Copy

    Entezari, Maedeh, BAKHTIARI, MEHRDAD, MORADI, FATEMEH, MOZAFARI, MASOUD, BAGHER, ZOHREH, & SOLEIMANI, MANSOUREH. (2023). Human Olfactory Ecto-mesenchymal Stem Cells Displaying Schwann-cell-like Phenotypes and Promoting Neurite Outgrowth in Vitro. BASIC AND CLINICAL NEUROSCIENCE, 14(1), 31-42. SID. https://sid.ir/paper/1070547/en

    Vancouver: Copy

    Entezari Maedeh, BAKHTIARI MEHRDAD, MORADI FATEMEH, MOZAFARI MASOUD, BAGHER ZOHREH, SOLEIMANI MANSOUREH. Human Olfactory Ecto-mesenchymal Stem Cells Displaying Schwann-cell-like Phenotypes and Promoting Neurite Outgrowth in Vitro. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2023;14(1):31-42. Available from: https://sid.ir/paper/1070547/en

    IEEE: Copy

    Maedeh Entezari, MEHRDAD BAKHTIARI, FATEMEH MORADI, MASOUD MOZAFARI, ZOHREH BAGHER, and MANSOUREH SOLEIMANI, “Human Olfactory Ecto-mesenchymal Stem Cells Displaying Schwann-cell-like Phenotypes and Promoting Neurite Outgrowth in Vitro,” BASIC AND CLINICAL NEUROSCIENCE, vol. 14, no. 1, pp. 31–42, 2023, [Online]. Available: https://sid.ir/paper/1070547/en

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