Association of Gene Polymorphisms in CXC Chemokine Receptor 5 with Rheumatoid Arthritis Susceptibility

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Su Zhenzhen; CHEN LIN; Niu Qian; YANG BIN; Huang Zhuochun

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Journal: IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY Year:2022 | Volume:21 | Issue:5 Page(s): 537-548

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Title

Association of Gene Polymorphisms in CXC Chemokine Receptor 5 with Rheumatoid Arthritis Susceptibility

Author(s)

Keywords

CXC chemokine receptor 5

Disease susceptibility

Rheumatoid arthritis

Single nucleotide polymorphism

Abstract

Rheumatoid arthritis (RA) is caused by complicated interactions between genes and the environment. CXC chemokine receptor 5 (CXCR5) is required for B and T follicular helper cell migration and humoral immunity generation. Therefore, this study aimed to assess whether polymorphisms of the CXCR5 gene are implicated in RA development and progression. This case-control study enrolled 285 RA patients and 291 healthy controls. The polymerase chain reaction-ligase detection reaction method was used to genotype rs630923, rs497916, rs3922, and rs676925 in the CXCR5 gene. Epidemiological, clinical, and laboratory data were collected retrospectively. The rs630923 A allele was associated with a higher risk of RA (AOR [adjusted odds ratio]=2. 00, 95% confidence interval [CI] =1. 14–, 3. 53). However, in the RA group, the frequency of the rs497916 T allele was lower (AOR=0. 69, 95% CI=0. 51–, 0. 93). Regarding rs3922, AG+GG genotype carriers were at a significantly lower risk for RA than AA genotype carriers (AOR=0. 70, 95% CI=0. 49–, 0. 99). In the RA group, we found that the different genotypes were significantly associated with specific laboratory values, including rheumatoid factor, total bilirubin, total cholesterol, low-density lipoprotein cholesterol, and alkaline phosphatase. This is the first report indicating that CXCR5 polymorphisms were associated with RA susceptibility. These findings lead to a rising possibility of identifying RA-susceptible individuals based on genetic markers.

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APA: Copy

Su, Zhenzhen, CHEN, LIN, Niu, Qian, YANG, BIN, & Huang, Zhuochun. (2022). Association of Gene Polymorphisms in CXC Chemokine Receptor 5 with Rheumatoid Arthritis Susceptibility. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 21(5), 537-548. SID. https://sid.ir/paper/1075569/en

Vancouver: Copy

Su Zhenzhen, CHEN LIN, Niu Qian, YANG BIN, Huang Zhuochun. Association of Gene Polymorphisms in CXC Chemokine Receptor 5 with Rheumatoid Arthritis Susceptibility. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2022;21(5):537-548. Available from: https://sid.ir/paper/1075569/en

IEEE: Copy

Zhenzhen Su, LIN CHEN, Qian Niu, BIN YANG, and Zhuochun Huang, “Association of Gene Polymorphisms in CXC Chemokine Receptor 5 with Rheumatoid Arthritis Susceptibility,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 21, no. 5, pp. 537–548, 2022, [Online]. Available: https://sid.ir/paper/1075569/en

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