THE ROLE OF ENDOTHELIAL-DERIVE FACTORS IN ACUTE MOUNTAIN SICKNESS

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FAYAZI BAYAN; TADIBI VAHID; BEHPOUR NASER; HEDAYATI MEHDI

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Journal: Journal of Knowledge & Health in Basic Medical Sciences Year:2017 | Volume:12 | Issue:3 Page(s): 17-24

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Title

THE ROLE OF ENDOTHELIAL-DERIVE FACTORS IN ACUTE MOUNTAIN SICKNESS

Author(s)

FAYAZI BAYAN | TADIBI VAHID | BEHPOUR NASER | HEDAYATI MEHDI | Issue Writer Certificate

Keywords

ACUTE MOUNTAIN SICKNESSQ2

VEGFQ2

ENDOTHELIN-1Q2

Abstract

Introduction: ACUTE MOUNTAIN SICKNESS (AMS) that caused by rapid ascent to altitude, is a pathophysiological symptom complex. Accordingly, aim of the study was to investigate the endothelial related factors changes in individual with a weak tolerance to high altitude.Methods: 21 healthy male (31.7±8.5 year) participated in the study and fasting blood samples were taken from antecubital vein before (sea level) and after 1 and 24-h exposure to high altitude (3550 m) by telecabin. Then, Serum VEGF and ENDOTHELIN-1 were measured by ELISA method. AMS status was measured by the Lake Louise score at 6 h after exposure to high altitude.Results: 11 of participants suffer from AMS. Statistical analyses showed that serum VEGF and ENDOTHELIN-1 at sea level in AMS-susceptible individuals were less than that of AMS-resistant individuals (P£0.05). VEGF and Endothelin levels were significantly increased at 1 and 24 h after exposure to altitude in two groups (P£0.05). The levels of VEGF and ENDOTHELIN-1 at tree time points were more in AMS-resistant individuals in compared to AMS-susceptible individuals (P£0.05).Conclusion: The results showed that the response of these proteins after exposure to altitude in AMS susceptibility individuals was less than AMS-resistant individuals. Susceptibility to AMS may be associated with a less response of VEGF and ENDOTHELIN-1 after exposure to altitude.

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APA: Copy

FAYAZI, BAYAN, TADIBI, VAHID, BEHPOUR, NASER, & HEDAYATI, MEHDI. (2017). THE ROLE OF ENDOTHELIAL-DERIVE FACTORS IN ACUTE MOUNTAIN SICKNESS. KNOWLEDGE AND HEALTH, 12(3 ), 17-24. SID. https://sid.ir/paper/107819/en

Vancouver: Copy

FAYAZI BAYAN, TADIBI VAHID, BEHPOUR NASER, HEDAYATI MEHDI. THE ROLE OF ENDOTHELIAL-DERIVE FACTORS IN ACUTE MOUNTAIN SICKNESS. KNOWLEDGE AND HEALTH[Internet]. 2017;12(3 ):17-24. Available from: https://sid.ir/paper/107819/en

IEEE: Copy

BAYAN FAYAZI, VAHID TADIBI, NASER BEHPOUR, and MEHDI HEDAYATI, “THE ROLE OF ENDOTHELIAL-DERIVE FACTORS IN ACUTE MOUNTAIN SICKNESS,” KNOWLEDGE AND HEALTH, vol. 12, no. 3 , pp. 17–24, 2017, [Online]. Available: https://sid.ir/paper/107819/en

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