The Effect of Four Weeks of High Intensity Interval Training with Curcumin Supplement on the Expression of IRS-1 and IRE-1α,Genes in the Left Ventricle of Type 2 Diabetic Rats

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Babaee Sedigheh; PEERI MAGHSOUD; AZARBAYJANI MOHAMMAD ALI; DELFAN MARYAM

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Journal: IRANIAN JOURNAL OF DIABETES AND METABOLISM Year:2023 | Volume:23 | Issue:1 Page(s): 24-33

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Title

The Effect of Four Weeks of High Intensity Interval Training with Curcumin Supplement on the Expression of IRS-1 and IRE-1α,Genes in the Left Ventricle of Type 2 Diabetic Rats

Author(s)

Babaee Sedigheh | PEERI MAGHSOUD | AZARBAYJANI MOHAMMAD ALI | DELFAN MARYAM | Issue Writer Certificate

Keywords

Myocrdial Apoptosis

Cardiomyopathy

Curcumin Supplement

High Intensity Interval Training

Abstract

Background: Impaired insulin function with exogenous changes is a major cause of heart failure. The purpose of this study was to investigate the effect of four weeks of high intensity interval training with curcumin supplement on the expression of IRS-1 and IRE-1α,gene in the Left ventricle of type 2 diabetic rats. Methods: In the present experimental study, 30 male mice with diabetes were divided into five groups of 6,high intensity interval training (HIIT), High intensity interval Training+Curcumin(S+HIIT), Diabetic control+curcumin(S+DC), Diabetic Control (DC), Normal control (NC). The High intensity interval training protocol was performed five days a week for four weeks. Curcumin gavage at a dose of 100 mg/kg was performed daily. The expression of IRS-1 and IRE-1α,were measured by the qReal-TimePCR method, and data were analyzed by one-way ANOVA at the alpha level of 0. 05. Results: IRS-1 gene expression in the S+HIIT group compared to the DC (P=0. 003) and S+DC (P=0. 001) groups and in the HIIT group compared to the DC (P=0. 002), and S groups +DC had a significant decrease (P=0. 019). IRE-1α,gene was significantly decreased in S+HIIT group compared to DC (P=0. 003), S+DC (P=0. 001) and HIIT (P=0. 008) groups. Conclusion: It seems that HIIT with curcumin supplement can reduce the process of myocardial apoptosis in diabetic patients by improving metabolic conditions and genetic factors.

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APA: Copy

Babaee, Sedigheh, PEERI, MAGHSOUD, AZARBAYJANI, MOHAMMAD ALI, & DELFAN, MARYAM. (2023). The Effect of Four Weeks of High Intensity Interval Training with Curcumin Supplement on the Expression of IRS-1 and IRE-1α,Genes in the Left Ventricle of Type 2 Diabetic Rats. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 23(1 ), 24-33. SID. https://sid.ir/paper/1080263/en

Vancouver: Copy

Babaee Sedigheh, PEERI MAGHSOUD, AZARBAYJANI MOHAMMAD ALI, DELFAN MARYAM. The Effect of Four Weeks of High Intensity Interval Training with Curcumin Supplement on the Expression of IRS-1 and IRE-1α,Genes in the Left Ventricle of Type 2 Diabetic Rats. JOURNAL OF DIABETES AND METABOLIC DISORDERS[Internet]. 2023;23(1 ):24-33. Available from: https://sid.ir/paper/1080263/en

IEEE: Copy

Sedigheh Babaee, MAGHSOUD PEERI, MOHAMMAD ALI AZARBAYJANI, and MARYAM DELFAN, “The Effect of Four Weeks of High Intensity Interval Training with Curcumin Supplement on the Expression of IRS-1 and IRE-1α,Genes in the Left Ventricle of Type 2 Diabetic Rats,” JOURNAL OF DIABETES AND METABOLIC DISORDERS, vol. 23, no. 1 , pp. 24–33, 2023, [Online]. Available: https://sid.ir/paper/1080263/en

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