DESIGN OF NANOPARTICLES LOADED ACYCLOVIR FOR CONTROLLED DELIVERY SYSTEM

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAHSAVARI SHADAB; ABEDIN DORKOOSH FARID; VASHEGHANI FARAHANI EBRAHIM; ARJMAND MEHDI

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,561

Download:

Cites:

Information Journal Paper

Title

DESIGN OF NANOPARTICLES LOADED ACYCLOVIR FOR CONTROLLED DELIVERY SYSTEM

Author(s)

SHAHSAVARI SHADAB | ABEDIN DORKOOSH FARID | VASHEGHANI FARAHANI EBRAHIM | ARJMAND MEHDI | Issue Writer Certificate

Keywords

ACYCLOVIRQ3

CHITOSAN NANOPARTICLESQ3

CONTROLLED RELEASE SYSTEMQ3

D-OPTIMAL RESPONSE SURFACE EXPERIMENTAL DESIGN METHODOLOGYQ3

IONIC GELATIONQ3

Abstract

Introduction: The aim of this research was to develop a new drug release systems based on Nanoparticles. In this study, the natural polymer chitosan was used for preparation of nanoparticles due to its unique properties, such as biocompatibility and biodegradability.Methods: The polymeric nano-drug CONTROLLED RELEASE SYSTEM has been designed with experimental design D-optimal response surface methodology, for varied variables such as the concentration of ACYCLOVIR, concentration ratio of chitosan/ TPP and pH using the IONIC GELATION method. The nanoparticles were characterized morphologically by scanning electron microcopy (SEM), particle size analyser (DLS) for determining size, zeta and PdI, Fourier Transform Infra-Red (FTIR) Spectroscopy for determination of structure of nanoparticlesand thermo gravimetric analysis (TGA)for studying thermal behavior. The optimized nanoparticles were characterized.Results: The size of the particles was detected to be 132±24.3 nm; zeta potential was 32±2.87 mV; PdI of particles was 0.159±0.05; and calculated EE% was 85±4.38%. An in-vitro release study of the prepared nanoparticles illustrated that the percentage of ACYCLOVIR released from the nanoparticles was 80.17±2.45% within 48 hrs.Conclusion: The optimized nanoparticles according to SEM image, exhibited segregated and non-aggregated nanoparticles with sub-spherical smooth morphology and also the high thermal stability of ACYCLOVIR nanoparticles at temperature up to 200°C due to TGA analysis, which indicated a well-established structure of nanoparticles.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAHSAVARI, SHADAB, ABEDIN DORKOOSH, FARID, VASHEGHANI FARAHANI, EBRAHIM, & ARJMAND, MEHDI. (2015). DESIGN OF NANOPARTICLES LOADED ACYCLOVIR FOR CONTROLLED DELIVERY SYSTEM. KNOWLEDGE AND HEALTH, 9(4), 60-67. SID. https://sid.ir/paper/108054/en

Vancouver: Copy

SHAHSAVARI SHADAB, ABEDIN DORKOOSH FARID, VASHEGHANI FARAHANI EBRAHIM, ARJMAND MEHDI. DESIGN OF NANOPARTICLES LOADED ACYCLOVIR FOR CONTROLLED DELIVERY SYSTEM. KNOWLEDGE AND HEALTH[Internet]. 2015;9(4):60-67. Available from: https://sid.ir/paper/108054/en

IEEE: Copy

SHADAB SHAHSAVARI, FARID ABEDIN DORKOOSH, EBRAHIM VASHEGHANI FARAHANI, and MEHDI ARJMAND, “DESIGN OF NANOPARTICLES LOADED ACYCLOVIR FOR CONTROLLED DELIVERY SYSTEM,” KNOWLEDGE AND HEALTH, vol. 9, no. 4, pp. 60–67, 2015, [Online]. Available: https://sid.ir/paper/108054/en

Related Journal Papers