Serum Evaluation of Helicobacter pylori in Patients with Multiple Sclerosis

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MESHKAT MOJTABA; Behjati Yeganeh; Bakhshi Mansooreh; MESHKAT ZAHRA; Yazdan Mehr Mina; BOOSTANI REZA; SAEIDI MORTEZA; Khoshakhlagh Mahdieh; Hooshyar Chechaklou Amin; Najjari Mahya; Abolbashari Samaneh; GHOLOOBI AIDA

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Journal: ARCHIVES OF NEUROSCIENCE Year:2023 | Volume:10 | Issue:3 Page(s): 0-0

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Title

Serum Evaluation of Helicobacter pylori in Patients with Multiple Sclerosis

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Keywords

Helicobacter pylori

Multiple Sclerosis

Serology

IgG Antibodies

Abstract

Background: Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous system of unknown etiology, which is believed to be caused by immune dysregulation triggered by genetic and environmental factors, leading to demyelination and axonal loss. Researchers consider infectious agents, like Helicobacter pylori, as these environmental factors. H. pylori can permanently infect someone’, s stomach and cause an acute or chronic inflammatory response, in which inflammatory mediators affect the brain and cause a pathologic disease. Methods: In this cross-sectional study, 38 patients with multiple sclerosis who were referred to the Neurology Clinic of Ghaem Hospital were included, and their serum samples were analyzed for IgM, IgA, and IgG antibodies against H. pylori by using enzyme-linkedimmunosorbentassay (ELISA). Resultswerecomparedwith the samples of 41 sex-andage-matched controls admitted to other wards of Ghaem Hospital & had no symptoms of MS. In the end, we analyzed the data with SPSS v. 20. Results: In this study, 79 patients, including 38 patients with MS disease in the case group and 41 healthy individuals in the control group, were studied. These two groups had no significant differences in demographic characteristics, including age, gender, and occupation. H. pylori seropositivity was significantly higher in patients with MS than in controls (68. 4% vs 39%) (P = 0. 009). In addition, comparing H. pylori seropositivity in 20 of 30 patients with relapsing-remitting MS versus 6 of 8 patients with progressive MSsuggested a significant difference between these two groups (P = 0. 030). Also, H. pylori seropositivityhadnosignificant difference between males and females (39. 1% vs 58. 9%). Conclusions: The prevalence of H. pylori seropositivity was significantly higher in patients with MS than in control, besides this seems more frequent in a progressive type of MS than in a relapsing-remitting one, suggesting that H. pylori might be a causal factor for developing & progressing MS and this may have an adverse impact on the prognosis and course of the disease.

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APA: Copy

MESHKAT, MOJTABA, Behjati, Yeganeh, Bakhshi, Mansooreh, MESHKAT, ZAHRA, Yazdan Mehr, Mina, BOOSTANI, REZA, SAEIDI, MORTEZA, Khoshakhlagh, Mahdieh, Hooshyar Chechaklou, Amin, Najjari, Mahya, Abolbashari, Samaneh, & GHOLOOBI, AIDA. (2023). Serum Evaluation of Helicobacter pylori in Patients with Multiple Sclerosis. ARCHIVES OF NEUROSCIENCE, 10(3), 0-0. SID. https://sid.ir/paper/1091846/en

Vancouver: Copy

MESHKAT MOJTABA, Behjati Yeganeh, Bakhshi Mansooreh, MESHKAT ZAHRA, Yazdan Mehr Mina, BOOSTANI REZA, SAEIDI MORTEZA, Khoshakhlagh Mahdieh, Hooshyar Chechaklou Amin, Najjari Mahya, Abolbashari Samaneh, GHOLOOBI AIDA. Serum Evaluation of Helicobacter pylori in Patients with Multiple Sclerosis. ARCHIVES OF NEUROSCIENCE[Internet]. 2023;10(3):0-0. Available from: https://sid.ir/paper/1091846/en

IEEE: Copy

MOJTABA MESHKAT, Yeganeh Behjati, Mansooreh Bakhshi, ZAHRA MESHKAT, Mina Yazdan Mehr, REZA BOOSTANI, MORTEZA SAEIDI, Mahdieh Khoshakhlagh, Amin Hooshyar Chechaklou, Mahya Najjari, Samaneh Abolbashari, and AIDA GHOLOOBI, “Serum Evaluation of Helicobacter pylori in Patients with Multiple Sclerosis,” ARCHIVES OF NEUROSCIENCE, vol. 10, no. 3, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1091846/en

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