THE EFFECTS OF SALVIA OFFICINALIS EXTRACT ON SERUM LEVEL OF CEA IN MALE RATS

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AHMADI RAHIM; HODAVAND MIRZAEE ZAHRA; MAFI MAHYAR

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Journal: Razi Journal of Medical Sciences Year:2012 | Volume:19 | Issue:100 Page(s): 37-42

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Title

THE EFFECTS OF SALVIA OFFICINALIS EXTRACT ON SERUM LEVEL OF CEA IN MALE RATS

Author(s)

AHMADI RAHIM | HODAVAND MIRZAEE ZAHRA | MAFI MAHYAR | Issue Writer Certificate

Keywords

SALVIA OFFICINALISQ2

CEAQ2

RATQ2

Abstract

Background: There are few studies indicating the association of Salvia officinal is extract with tumor markers. The main aim of this study was to determine the effects of Salvia officinallis extract on serum level of CEA (Carcinogenic embryonic antigen) in male RATs.Methods: In this laboratory experimental study, male Wistar RATs were randomly divided into control, normal saline or SALVIA OFFICINALIS extract (100 or 200 mg/kg/body weight) receiving animals of 5 in each group. After 7 weeks blood samples were collected using cardiac puncture method. Following serum collection, CEA level was measured by radioimmunoassay method. Data were statistically analyzed and compared between groups using ANOVA.Results: The results indicated that serum CEA level was significantly decreased in RATs receiving SALVIA OFFICINALIS extract (200 mg/kg/body weight) compared with control animals (P<0.05), however, CEA serum level was not significantly changed in RATs receiving 100mg/kg/body weight of extract compared to control animals Conclusion: Our findings show that appropriate dose of SALVIA OFFICINALIS extract can decrease serum level of CEA, on which medicinal application of this extract particularly in cancers accompanied by CEA increased serum level is conceivable.

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APA: Copy

AHMADI, RAHIM, HODAVAND MIRZAEE, ZAHRA, & MAFI, MAHYAR. (2012). THE EFFECTS OF SALVIA OFFICINALIS EXTRACT ON SERUM LEVEL OF CEA IN MALE RATS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 19(100), 37-42. SID. https://sid.ir/paper/10960/en

Vancouver: Copy

AHMADI RAHIM, HODAVAND MIRZAEE ZAHRA, MAFI MAHYAR. THE EFFECTS OF SALVIA OFFICINALIS EXTRACT ON SERUM LEVEL OF CEA IN MALE RATS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2012;19(100):37-42. Available from: https://sid.ir/paper/10960/en

IEEE: Copy

RAHIM AHMADI, ZAHRA HODAVAND MIRZAEE, and MAHYAR MAFI, “THE EFFECTS OF SALVIA OFFICINALIS EXTRACT ON SERUM LEVEL OF CEA IN MALE RATS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 19, no. 100, pp. 37–42, 2012, [Online]. Available: https://sid.ir/paper/10960/en

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