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Information Journal Paper

Title

Assessment of Esophageal Motility Disorders in Patients With Refractory Gastroesophageal Reflux Disease

Pages

  616-621

Keywords

Refractory gastroesophageal reflux disease (RGERD) 
High-resolution manometry (HRM) 
Multichannel intraluminal impedance-pH (MII-Ph) monitoring 
Ineffective esophageal motility (IEM) 

Abstract

 There is insufficient data about esophageal body dysmotility in patients with refractory gastroesophageal reflux disease (RGERD) and inadequate response to proton pump inhibitors (PPIs) treatment. This study aimed to assess esophageal motility disorder and reflux parameters among these patients by highresolution manometry (HRM) and intraluminal impedance and pH (MII‐,pH) monitoring after stopping PPI therapy. A retrospective study was conducted among 100 RGERD patients admitted to Taleghani Hospital (Tehran, Iran) for one year. More than half of them were males (55%). Their mean age was 47. 10±, 6. 92, and 50% of patients had ineffective esophageal motility (IEM). Middle, distal, and proximal esophageal pressure (MEP, DEP, and PEP), lower esophageal sphincter (LES) basal pressure (LESP), integrated relaxation pressure (IRP), distal contractile integral (DCI), large breaks, upper esophageal sphincter basal pressure (UESP), and LES length (LESL) in IEM patients were significantly lower than the patients with normal esophageal motility (P<0. 001). Furthermore, there were more patients in the IEM group with long-term and abnormal weakly acid reflux compared with the non-IEM group (P<0. 05). It seems that the evaluation of reflux parameters and esophageal motility could lead to additional insights into the pathophysiological mechanisms of RGERD. Nevertheless, further studies are suggested to evaluate the effects of esophageal motility disorders among RGERD patients.

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    • Cite

    APA: Copy

    Bagherzadeh, Asghar, ABDI, SAEED, ZALI, MOHAMMAD REZA, & Mohammadi, Shooka. (2022). Assessment of Esophageal Motility Disorders in Patients With Refractory Gastroesophageal Reflux Disease. ACTA MEDICA IRANICA, 60(10), 616-621. SID. https://sid.ir/paper/1101465/en

    Vancouver: Copy

    Bagherzadeh Asghar, ABDI SAEED, ZALI MOHAMMAD REZA, Mohammadi Shooka. Assessment of Esophageal Motility Disorders in Patients With Refractory Gastroesophageal Reflux Disease. ACTA MEDICA IRANICA[Internet]. 2022;60(10):616-621. Available from: https://sid.ir/paper/1101465/en

    IEEE: Copy

    Asghar Bagherzadeh, SAEED ABDI, MOHAMMAD REZA ZALI, and Shooka Mohammadi, “Assessment of Esophageal Motility Disorders in Patients With Refractory Gastroesophageal Reflux Disease,” ACTA MEDICA IRANICA, vol. 60, no. 10, pp. 616–621, 2022, [Online]. Available: https://sid.ir/paper/1101465/en

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