THE ROLE OF PIRIFORM CORTEX ADENOSINE A1 RECEPTORS IN HIPPOCAMPAL KINDLED SEIZURES IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAMVAR S.; MIRNAJAFIZADEH S.J.; REZVANI M.E.; HOSSEINMARDI N.; ZERAATI M.; SHAHABI P.; GHORBANI P.; FATH ELAHI Y.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Razi Journal of Medical Sciences Year:2006 | Volume:13 | Issue:51 Page(s): 197-204

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

739

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF PIRIFORM CORTEX ADENOSINE A1 RECEPTORS IN HIPPOCAMPAL KINDLED SEIZURES IN RATS

Author(s)

Keywords

SEIZUREQ2

KINDLINGQ2

HIPPOCAMPUSQ2

PIRIFORM CORTEXQ3

ADENOSINE A1 RECEPTORSQ3

Abstract

Background & Aim: Hippocampal CA1 region is the most common area in the development of temporal lobe epilepsy and PIRIFORM CORTEX is recognized as an important structure involved in the control of kindled SEIZUREs. This fundamental study dealt with the role of ADENOSINE A1 RECEPTORS of PIRIFORM CORTEX in CA1 hippocampal kindled SEIZUREs in rats.Material & Method: We implanted a tripolar electrod in the right hippocampal CA1 and two guide cannulae in the left and right PIRIFORM CORTEX of all the studied animals. In fully kindled animals, N6-cyclohexyladenosine (CHA; a selective ADENOSINE A1 RECEPTORS agonist injected at concentrations of 1,10 and 100 μm) and 1,3-dimethyl-8- cyclopenthylxantine (CPT; a selective ADENOSINE A1 RECEPTORS antagonist injected at concentrations of 10 and 20 μm) were microinfused into the PIRIFORM CORTEX and the animals were stimulated 5, 15 and 90 minutes after the drug injection.Results: Obtained data showed that CHA infusion at concentrations of 10 μm and 100 μm reduced afterdischarge duration (ADD), stage 5 SEIZURE duration (S5D), and total SEIZURE duration (SD). Stage 4 latency (S4L) did not change significantly. On the other hand, CPT injection at concentration of 20 μm increased ADD, S5D, SD and decreased S4L significantly. Infusion of CPT (10 μm) 5 minutes before CHA(100 μm) microinjection reduced the effects of CHA on SEIZURE parameters.Conclusion: Thus, it can be concluded that the activity of ADENOSINE A1 RECEPTORS in the PIRIFORM CORTEX has anticonvulsant effects on CA1 hippocampal kindled SEIZUREs.

Cites

No record.

References

No record.

Cite

APA: Copy

NAMVAR, S., MIRNAJAFIZADEH, S.J., REZVANI, M.E., HOSSEINMARDI, N., ZERAATI, M., SHAHABI, P., GHORBANI, P., & FATH ELAHI, Y.. (2006). THE ROLE OF PIRIFORM CORTEX ADENOSINE A1 RECEPTORS IN HIPPOCAMPAL KINDLED SEIZURES IN RATS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 13(51), 197-204. SID. https://sid.ir/paper/11125/en

Vancouver: Copy

NAMVAR S., MIRNAJAFIZADEH S.J., REZVANI M.E., HOSSEINMARDI N., ZERAATI M., SHAHABI P., GHORBANI P., FATH ELAHI Y.. THE ROLE OF PIRIFORM CORTEX ADENOSINE A1 RECEPTORS IN HIPPOCAMPAL KINDLED SEIZURES IN RATS. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2006;13(51):197-204. Available from: https://sid.ir/paper/11125/en

IEEE: Copy

S. NAMVAR, S.J. MIRNAJAFIZADEH, M.E. REZVANI, N. HOSSEINMARDI, M. ZERAATI, P. SHAHABI, P. GHORBANI, and Y. FATH ELAHI, “THE ROLE OF PIRIFORM CORTEX ADENOSINE A1 RECEPTORS IN HIPPOCAMPAL KINDLED SEIZURES IN RATS,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 13, no. 51, pp. 197–204, 2006, [Online]. Available: https://sid.ir/paper/11125/en

Related Journal Papers