The Effects of Memantine on the Glasgow Coma Scale, Sequential Organ Failure Assessment Score, and Neuron-Specific Enolase Serum Levels in Traumatic Brain Injury Patients

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RAMEZANI AHMAD; ALA SHAHRAM; Ehteshami Saeed; HEYDARI FATEMEH; SALEHIFAR EBRAHIM; SHAFIZAD MISAGH; Hadadi Kaveh; ABEDIANKENARI SAEID; MOOSAZADEH MAHMOOD

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Journal: JOURNAL OF NURSING AND MIDWIFERY SCIENCES Year:2023 | Volume:10 | Issue:1 Page(s): 0-0

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Title

The Effects of Memantine on the Glasgow Coma Scale, Sequential Organ Failure Assessment Score, and Neuron-Specific Enolase Serum Levels in Traumatic Brain Injury Patients

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Keywords

Memantine

Traumatic Brain Injury

Neuron-Specific Enolase

Glasgow Coma Scale

Sequential Organ Failure Assessment Score

Abstract

Background: Traumatic brain injury (TBI) causes disability and death in many patients. Objectives: We investigated the eﬀ, ect of memantine on the Glasgow Coma Scale (GCS), serum levels of neuron-speciﬁ, c enolase (NSE), and its eﬀ, ect on sequential organ failure assessment (SOFA) score in TBI patients with GCS 6-12 on days 1, 3, and 7. Methods: Fifty-nine patients were randomly divided into intervention (n = 29) and control (n = 30) groups who received 30mg drug/placebo every 12 hours for seven days with standard treatment, respectively. The acute physiology and chronic health evaluation II and head CT scan ﬁ, ndings were collected on the ﬁ, rst day, and the Glasgow Outcome Scale Extended 90 was collected three months later. Results: Considering patients with GCS 6-12, the SOFA and NSE decreased from day 1-7 in both memantine and control groups, about NSE by 21% and 12. 6%, respectively. In GCS6-8 subgroup, the NSE decreased by 19. 1% in the memantine group and increased by 8. 45%, in the control group. In GCS 9-12 subgroup, the NSE decreased by 52. 6% and 24. 43% in the memantine and control groups, respectively. The SOFA changes were signiﬁ, cant between memantine and control groups on day 3 in GCS 9-12 subgroup (P = 0. 01). In the memantine group with GCS 6-12, the increase of GCS from day 1-7 was signiﬁ, cant (29. 6%, P = 0. 002), and also in both GCS subgroups. Comparing memantine and control groups, the improvement of GCS was signiﬁ, cant on days 3 and 7 in GCS 9-12 subgroup. Conclusions: This trial showed that memantine improved the neurohormonal and clinical status of TBI patients with GCS 6-12.

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APA: Copy

RAMEZANI, AHMAD, ALA, SHAHRAM, Ehteshami, Saeed, HEYDARI, FATEMEH, SALEHIFAR, EBRAHIM, SHAFIZAD, MISAGH, Hadadi, Kaveh, ABEDIANKENARI, SAEID, & MOOSAZADEH, MAHMOOD. (2023). The Effects of Memantine on the Glasgow Coma Scale, Sequential Organ Failure Assessment Score, and Neuron-Specific Enolase Serum Levels in Traumatic Brain Injury Patients. JOURNAL OF NURSING AND MIDWIFERY SCIENCES, 10(1), 0-0. SID. https://sid.ir/paper/1128855/en

Vancouver: Copy

RAMEZANI AHMAD, ALA SHAHRAM, Ehteshami Saeed, HEYDARI FATEMEH, SALEHIFAR EBRAHIM, SHAFIZAD MISAGH, Hadadi Kaveh, ABEDIANKENARI SAEID, MOOSAZADEH MAHMOOD. The Effects of Memantine on the Glasgow Coma Scale, Sequential Organ Failure Assessment Score, and Neuron-Specific Enolase Serum Levels in Traumatic Brain Injury Patients. JOURNAL OF NURSING AND MIDWIFERY SCIENCES[Internet]. 2023;10(1):0-0. Available from: https://sid.ir/paper/1128855/en

IEEE: Copy

AHMAD RAMEZANI, SHAHRAM ALA, Saeed Ehteshami, FATEMEH HEYDARI, EBRAHIM SALEHIFAR, MISAGH SHAFIZAD, Kaveh Hadadi, SAEID ABEDIANKENARI, and MAHMOOD MOOSAZADEH, “The Effects of Memantine on the Glasgow Coma Scale, Sequential Organ Failure Assessment Score, and Neuron-Specific Enolase Serum Levels in Traumatic Brain Injury Patients,” JOURNAL OF NURSING AND MIDWIFERY SCIENCES, vol. 10, no. 1, pp. 0–0, 2023, [Online]. Available: https://sid.ir/paper/1128855/en

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