EVALUATING TAMOXIFEN EFFECT IN THE PREVENTION OF HYPERTROPHIC SCARS FOLLOWING SURGICAL INCISIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOUSAVI SEYED REZA; ZEYNALZADEH MOHAMMAD; SABERI GHOUCHANI A.R.; AMINSERESHT M.; TALEBIANFAR M.; KAVIANI ALI; SARVARIAN S.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Surgery Year:2008 | Volume:15 | Issue:4 Page(s): 54-59

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

940

Download:

Cites:

Information Journal Paper

Title

EVALUATING TAMOXIFEN EFFECT IN THE PREVENTION OF HYPERTROPHIC SCARS FOLLOWING SURGICAL INCISIONS

Author(s)

Keywords

HYPERTROPHIC SCARQ4

TAMOXIFENQ3

CLINICAL TRIALQ4

Abstract

Introduction & Objective: HYPERTROPHIC SCARs (HTS) following surgical incisions develop mainly due to fibroblast dysfunction in wound healing process, and it may cause significant psychological and social consequences in various patient populations. With regard to growing evidence on TAMOXIFEN effects on fibroblast growth patterns at the cellular level, this study was designated to evaluate the clinical utility of TAMOXIFEN in the prevention of HYPERTROPHIC SCARs, which had been carried out in Shohadaye Tajrish and Ayatollah Taleghani Medical Centers in the 2000 2001 time interval.Materials & Methods: In a double-blind randomized CLINICAL TRIAL after obtaining informed consent, of 300 patients with a history of HTS, who had undergone surgical operations with different skin incisions were assigned randomly into two groups. The first group received TAMOXIFEN tablets postoperatively according to a standard protocol while the control group received placebo. After two months the two groups were compared according to the development of HTS and the result was statistically analyzed.Results: The studied population, comprised of 235 men (78.7%) and 65 women (21.7%), developed HTS following surgical incision. Of these 138 patients (92%) were in the study group, while 78 patients (52%) belonged to control group.Conclusions: Regarding the significant difference of HTS development between the study and control groups (92% vs. 52%), TAMOXIFEN seems to be an effective agent in the prevention of HYPERTROPHIC SCARs following surgery.

Cites

No record.

References

No record.

Cite

APA: Copy

MOUSAVI, SEYED REZA, ZEYNALZADEH, MOHAMMAD, SABERI GHOUCHANI, A.R., AMINSERESHT, M., TALEBIANFAR, M., KAVIANI, ALI, & SARVARIAN, S.. (2008). EVALUATING TAMOXIFEN EFFECT IN THE PREVENTION OF HYPERTROPHIC SCARS FOLLOWING SURGICAL INCISIONS. IRANIAN JOURNAL OF SURGERY, 15(4), 54-59. SID. https://sid.ir/paper/112941/en

Vancouver: Copy

MOUSAVI SEYED REZA, ZEYNALZADEH MOHAMMAD, SABERI GHOUCHANI A.R., AMINSERESHT M., TALEBIANFAR M., KAVIANI ALI, SARVARIAN S.. EVALUATING TAMOXIFEN EFFECT IN THE PREVENTION OF HYPERTROPHIC SCARS FOLLOWING SURGICAL INCISIONS. IRANIAN JOURNAL OF SURGERY[Internet]. 2008;15(4):54-59. Available from: https://sid.ir/paper/112941/en

IEEE: Copy

SEYED REZA MOUSAVI, MOHAMMAD ZEYNALZADEH, A.R. SABERI GHOUCHANI, M. AMINSERESHT, M. TALEBIANFAR, ALI KAVIANI, and S. SARVARIAN, “EVALUATING TAMOXIFEN EFFECT IN THE PREVENTION OF HYPERTROPHIC SCARS FOLLOWING SURGICAL INCISIONS,” IRANIAN JOURNAL OF SURGERY, vol. 15, no. 4, pp. 54–59, 2008, [Online]. Available: https://sid.ir/paper/112941/en

Related Journal Papers