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Information Journal Paper

Title

The Effect of Eight Weeks of Endurance Training with Saffron on Cytochrome C and Calmodulin Kinase 2 on the Heart Tissue of Alzheimer’, s Rats Treated With Trimethyl Tin (TMT)

Pages

  152-157

Abstract

 Introduction: A proper diet and physical activity benefit Alzheimer’, s disease (AD). Therefore, this study aimed to evaluate the impact of endurance training (ET) with saffron (Sa) consumption on cytochrome C and calmodulin kinase 2 in the heart tissue of AD rats. Methods: In this experimental study, 40 rats (AD induced by intraperitoneal 8mg/kg trimethyl tin) were divided into five groups of eight animals comprising: (1) AD, (2) Endurance training (ET), (3) saffron (Sa), (4) ET+Sa, and (5) sham (Saffron solvent) groups. The ET and ET+Sa groups ran on a treadmill at 15 to 20m/min (three sessions a week for eight weeks), each lasting 15 to 30 minutes. In addition, the Sa and ET+Sa groups were given 25mg/kg saffron extract per day. The Shapiro-Wilk test, one-way ANOVA, and Tukey’, s post hoc tests were used to analyze the data (P≥, 0. 05). Results: ET, Sa, and ET+Sa significantly decreased cytochrome C and calmodulin kinase 2 (P≥, 0. 05). In addition, ET+Sa significantly reduced calmodulin kinase two more than training (P=0. 04). Conclusion: Based on the results, Training and saffron consumption appear to have the same impacts on reducing cytochrome C and calmodulin kinase 2. However, simultaneous training and saffron consumption can improve the gene expression levels of calmodulin kinase 2.

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    APA: Copy

    Azariyan, Maryam, Keshavarz, Saeid, HOSSEINI, SEYED ALI, & ZAHEDI, HAMID. (2023). The Effect of Eight Weeks of Endurance Training with Saffron on Cytochrome C and Calmodulin Kinase 2 on the Heart Tissue of Alzheimer’, s Rats Treated With Trimethyl Tin (TMT). JOURNAL OF NUTRITION, FASTING AND HEALTH, 11(2), 152-157. SID. https://sid.ir/paper/1142306/en

    Vancouver: Copy

    Azariyan Maryam, Keshavarz Saeid, HOSSEINI SEYED ALI, ZAHEDI HAMID. The Effect of Eight Weeks of Endurance Training with Saffron on Cytochrome C and Calmodulin Kinase 2 on the Heart Tissue of Alzheimer’, s Rats Treated With Trimethyl Tin (TMT). JOURNAL OF NUTRITION, FASTING AND HEALTH[Internet]. 2023;11(2):152-157. Available from: https://sid.ir/paper/1142306/en

    IEEE: Copy

    Maryam Azariyan, Saeid Keshavarz, SEYED ALI HOSSEINI, and HAMID ZAHEDI, “The Effect of Eight Weeks of Endurance Training with Saffron on Cytochrome C and Calmodulin Kinase 2 on the Heart Tissue of Alzheimer’, s Rats Treated With Trimethyl Tin (TMT),” JOURNAL OF NUTRITION, FASTING AND HEALTH, vol. 11, no. 2, pp. 152–157, 2023, [Online]. Available: https://sid.ir/paper/1142306/en

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