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Information Journal Paper

Title

EFFECTS OF NOISE STRESS DURING FETAL LIFE ON PAIN THRESHOLD IN RATS

Pages

  53-59

Abstract

 It has been shown that many types of physical - environmental stresses during FETAL LIFE alter behavioral responses to stimuli. Sex hormones have been shown to be evolved in these behaviors. Nociception can also be affected by stress, but the mechanism (s) are not fully investigated. In this study NMRI pregnant rats (220-250 gr) were exposed to repetitive one hour intermittent NOISE STRESS (90-120 db, low frequency, white noise) during night dark cycle. Intensity and frequency of noise varied each 2-3 minutes between minimum and maximum levels. Pain thershold was measured after after subcutaneous injection of 50 ul  formalin (2.5%) in right paw. The experimentmsubcutaneous injection of 50 considered to have two stages: 1) phasic pain, minutes 0-15 and 2) tonic pain minutes 20-50. Pain score was marked every 15 seconds. The results showed that exposing to NOISE STRESS during FETAL LIFE has mostly affected tonic PAIN THRESHOLD. PAIN THRESHOLD in stressed female offspring was increased significantly compared to stressed male offspring or compared to control male and female offspring. In conclusion it is suggested that NOISE STRESS during FETAL LIFE may increase PAIN THRESHOLD (hypoalgesia). Increase in endogenouse opioid release may be considered as the mechanism.

Cites

References

Cite

APA: Copy

SARKAKI, A.R., HEYDARI, A., & SHAHRAKI, M.. (2000). EFFECTS OF NOISE STRESS DURING FETAL LIFE ON PAIN THRESHOLD IN RATS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, 7(2), 53-59. SID. https://sid.ir/paper/115/en

Vancouver: Copy

SARKAKI A.R., HEYDARI A., SHAHRAKI M.. EFFECTS OF NOISE STRESS DURING FETAL LIFE ON PAIN THRESHOLD IN RATS. JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2000;7(2):53-59. Available from: https://sid.ir/paper/115/en

IEEE: Copy

A.R. SARKAKI, A. HEYDARI, and M. SHAHRAKI, “EFFECTS OF NOISE STRESS DURING FETAL LIFE ON PAIN THRESHOLD IN RATS,” JOURNAL OF KERMAN UNIVERSITY OF MEDICAL SCIENCES, vol. 7, no. 2, pp. 53–59, 2000, [Online]. Available: https://sid.ir/paper/115/en

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