STUDY OF PAI-1 4G/5G POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION

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IMANIAN HASHEM; HADAVI VALEH; KARIMINEJAD ARIANA; OBERKANINS CHRISTIAN; NAJMABADI HOSSEIN

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2010 | Volume:8 | Issue:1 Page(s): 1973-1977

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Title

STUDY OF PAI-1 4G/5G POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION

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Keywords

VENOUS THROMBOEMBOLISMQ3

POLYMORPHISMQ3

GENETICQ3

PLASMINOGEN ACTIVATOR INHIBITOR 1Q3

GENE FREQUENCYQ2

IRANQ2

Abstract

Two hundred and eight asymptomatic individuals from different origins of IRAN were included in this study in order to assess the distribution of the PAl-1 4G/5G POLYMORPHISM responding for cardiovascular disease (CVD) in the general IRANian population using a novel technique reverse hybridization Strip Assay for the rapid and simultaneous detection. The test is based on multiplex PCR and hybridization to a teststrip presenting a parallel array of allele-specific oligonucleotide probes. The allele frequency of mutant PAl-1 4G/5G (0.45) is comparable to that of Europeans, but exceeded the much lower frequencies known from the most of Asia. Here we describe the distribution of mutant allele PAl-1 4G/5G in different ethnicities of IRANian population. Our data represent the only comprehensive study to date with respect to thrombophilic gene POLYMORPHISM in IRAN.

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APA: Copy

IMANIAN, HASHEM, HADAVI, VALEH, KARIMINEJAD, ARIANA, OBERKANINS, CHRISTIAN, & NAJMABADI, HOSSEIN. (2010). STUDY OF PAI-1 4G/5G POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION. GENETICS IN THE 3RD MILLENNIUM, 8(1), 1973-1977. SID. https://sid.ir/paper/117210/en

Vancouver: Copy

IMANIAN HASHEM, HADAVI VALEH, KARIMINEJAD ARIANA, OBERKANINS CHRISTIAN, NAJMABADI HOSSEIN. STUDY OF PAI-1 4G/5G POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2010;8(1):1973-1977. Available from: https://sid.ir/paper/117210/en

IEEE: Copy

HASHEM IMANIAN, VALEH HADAVI, ARIANA KARIMINEJAD, CHRISTIAN OBERKANINS, and HOSSEIN NAJMABADI, “STUDY OF PAI-1 4G/5G POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION,” GENETICS IN THE 3RD MILLENNIUM, vol. 8, no. 1, pp. 1973–1977, 2010, [Online]. Available: https://sid.ir/paper/117210/en

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