STUDY OF PROTHROMBIN G20210A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION

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ROSTAMI MARYAM; HADAVI VALEH; KARIMINEJAD ARIANA; AFROOZAN FARIBA; IMANIAN HASHEM; OBERKANINS CHRISTIAN; NAJMABADI HOSSEIN

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Journal: GENETICS IN THE 3RD MILLENNIUM Year:2010 | Volume:8 | Issue:1 Page(s): 1967-1972

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Title

STUDY OF PROTHROMBIN G20210A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION

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Keywords

VENOUS THROMBOEMBOLISMQ3

POLYMORPHISMQ3

GENETINCQ3

GENETINC TESTINGQ3

GENE FREQUENCYQ2

PROTHROMBIMQ2

IRANQ2

Abstract

Two hundred and eight asymptomatic individuals from different origins of IRAN were included in this study in order to assess the distribution of the Prothrombin G20210A POLYMORPHISM responding for cardiovascular disease (CVD) in the general IRANian population using a novel technique reverse hybridization StripAssay for the rapid and simultaneous detection. The test is based on multiplex PCR and hybridization to a teststrip presenting a parallel array of allele-specific oligonucleotide probes for each mutation. The allele frequencies of mutant Prothrombin G20210A (0.005) in our cohort were below previously published figures on the population of Tehran (1.5). Here we describe the distribution of mutant allele Prothrombin G20210A in different ethnicities of IRANian population and compare the results to previously reported data. Our data represent the most comprehensive study to date with respect to thrombophilic gene POLYMORPHISM in IRAN.

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APA: Copy

ROSTAMI, MARYAM, HADAVI, VALEH, KARIMINEJAD, ARIANA, AFROOZAN, FARIBA, IMANIAN, HASHEM, OBERKANINS, CHRISTIAN, & NAJMABADI, HOSSEIN. (2010). STUDY OF PROTHROMBIN G20210A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION. GENETICS IN THE 3RD MILLENNIUM, 8(1), 1967-1972. SID. https://sid.ir/paper/117216/en

Vancouver: Copy

ROSTAMI MARYAM, HADAVI VALEH, KARIMINEJAD ARIANA, AFROOZAN FARIBA, IMANIAN HASHEM, OBERKANINS CHRISTIAN, NAJMABADI HOSSEIN. STUDY OF PROTHROMBIN G20210A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2010;8(1):1967-1972. Available from: https://sid.ir/paper/117216/en

IEEE: Copy

MARYAM ROSTAMI, VALEH HADAVI, ARIANA KARIMINEJAD, FARIBA AFROOZAN, HASHEM IMANIAN, CHRISTIAN OBERKANINS, and HOSSEIN NAJMABADI, “STUDY OF PROTHROMBIN G20210A POLYMORPHISM AS A GENETIC RISK FACTOR FOR CARDIOVASCULAR DISEASE IN THE IRANIAN POPULATION,” GENETICS IN THE 3RD MILLENNIUM, vol. 8, no. 1, pp. 1967–1972, 2010, [Online]. Available: https://sid.ir/paper/117216/en

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