APPLICATION OF DNA AS A VACCINE ADJUVANT

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NIKBAKHT BOREJENI GHOLAM REZA; GHORBANPOR REYHANE; BARJASTE NEDA

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Journal Paper

Paper Information

Journal: GENETICS IN THE 3RD MILLENNIUM Year:2010 | Volume:8 | Issue:3 Page(s): 2112-2121

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Information Journal Paper

Title

APPLICATION OF DNA AS A VACCINE ADJUVANT

Author(s)

NIKBAKHT BOREJENI GHOLAM REZA | GHORBANPOR REYHANE | BARJASTE NEDA | Issue Writer Certificate

Keywords

CPG ISLANDSQ3

TOLL-LIKE RECEPTOR 9Q3

ADJUVANTSQ3

IMMUNOLOGICQ3

Abstract

In the nature, organisms encounter different pathogens and microorganisms and in order to survive, they need to recognize and fight them. Pathogens include compounds in the structure of an organism such as lipopolysaccharides, nucleic acid and lipoproteins that can be recognized by the immune system. These compounds are known as Pathogen-Associated Molecular Patterns (PAMPs). A group of cell receptors that are named Toll-Like Receptors (TLR) recognize PAMPs. Today, at least 14 receptors in this family are discovered and each one is responsible for recognizing PAMPs. TLR9, one of these receptors, recognizes the DNA of bacteria and viruses. Stimulation of this receptor releases immune cells and activates both innate and adaptive immune systems. Sequences containing unmethylated CPG dinucleotides activate TOLL-LIKE RECEPTOR 9 (TLR9). Scientists make synthetic forms of CPG sequences and use them in many immune researches like vaccine ADJUVANTS. In addition, CPG dinucleotides can be used to stimulate the response of T lynphocytes against tumors, regulate cellular immune responses and activate humoral immunity.

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APA: Copy

NIKBAKHT BOREJENI, GHOLAM REZA, GHORBANPOR, REYHANE, & BARJASTE, NEDA. (2010). APPLICATION OF DNA AS A VACCINE ADJUVANT. GENETICS IN THE 3RD MILLENNIUM, 8(3), 2112-2121. SID. https://sid.ir/paper/117223/en

Vancouver: Copy

NIKBAKHT BOREJENI GHOLAM REZA, GHORBANPOR REYHANE, BARJASTE NEDA. APPLICATION OF DNA AS A VACCINE ADJUVANT. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2010;8(3):2112-2121. Available from: https://sid.ir/paper/117223/en

IEEE: Copy

GHOLAM REZA NIKBAKHT BOREJENI, REYHANE GHORBANPOR, and NEDA BARJASTE, “APPLICATION OF DNA AS A VACCINE ADJUVANT,” GENETICS IN THE 3RD MILLENNIUM, vol. 8, no. 3, pp. 2112–2121, 2010, [Online]. Available: https://sid.ir/paper/117223/en

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