DUAL ROLE, INTERACTIONS AND SIGNALING PATHWAYS OF P75 NTR IN THE NERVOUS SYSTEM

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MONTAZERI FATEMEH; ESMAEILI ABOLGHASEM; MIROLIAEI MEHRAN; MOSHTAGHIAN SEYED JAMAL

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Title

DUAL ROLE, INTERACTIONS AND SIGNALING PATHWAYS OF P75 NTR IN THE NERVOUS SYSTEM

Author(s)

MONTAZERI FATEMEH | ESMAEILI ABOLGHASEM | MIROLIAEI MEHRAN | MOSHTAGHIAN SEYED JAMAL | Issue Writer Certificate

Keywords

P75 NEUROTROPHIN RECEPTOR (P75NTR)Q2

SURVIVALQ2

APOPTOSISQ2

GENE EXPRESSIONQ2

SIGNALING TRANSDUCTIONQ2

INTERACTIONSQ2

NERVOUS SYSTEMQ2

Abstract

The p75 neurotrophin receptor (p75NTR) is a 75-kDa glycoprotein and the first identified member of the TNF receptor superfamily. p75NTR is initially expressed very early in embryogenesis in cells derived from all three germinal layers but becomes progressively restricted to specific cell populations such as CNS and PNS. The p75NTR expression is induced after pathologic conditions in a wide variety of cell types. p75NTR is a versatile protein, but its function in different cell types has remained enigmatic. One of the reasons for the lack of clarity regarding the function of p75NTR is that it does not signal by traditional pathways, it has no kinase activity nor is it linked to a G-protein-coupled pathway. p75NTR has no intrinsic enzymatic activity so it depends on its interaction with several adaptor proteins to signal the cascade for neuronal SURVIVAL or death. The various functions of p75 depend on the type of ligand bound to it (neurotrophins or pro- neurotrophins), the cell type in which it is expressed and the presence or absence of Trk receptor and Interaction with other receptors. This mini-review explores the function, GENE EXPRESSION, INTERACTIONS with co-receptors and signaling pathways of p75NTR in the NERVOUS SYSTEM.

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APA: Copy

MONTAZERI, FATEMEH, ESMAEILI, ABOLGHASEM, MIROLIAEI, MEHRAN, & MOSHTAGHIAN, SEYED JAMAL. (2011). DUAL ROLE, INTERACTIONS AND SIGNALING PATHWAYS OF P75 NTR IN THE NERVOUS SYSTEM. GENETICS IN THE 3RD MILLENNIUM, 9(2), 2401-2409. SID. https://sid.ir/paper/117227/en

Vancouver: Copy

MONTAZERI FATEMEH, ESMAEILI ABOLGHASEM, MIROLIAEI MEHRAN, MOSHTAGHIAN SEYED JAMAL. DUAL ROLE, INTERACTIONS AND SIGNALING PATHWAYS OF P75 NTR IN THE NERVOUS SYSTEM. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2011;9(2):2401-2409. Available from: https://sid.ir/paper/117227/en

IEEE: Copy

FATEMEH MONTAZERI, ABOLGHASEM ESMAEILI, MEHRAN MIROLIAEI, and SEYED JAMAL MOSHTAGHIAN, “DUAL ROLE, INTERACTIONS AND SIGNALING PATHWAYS OF P75 NTR IN THE NERVOUS SYSTEM,” GENETICS IN THE 3RD MILLENNIUM, vol. 9, no. 2, pp. 2401–2409, 2011, [Online]. Available: https://sid.ir/paper/117227/en

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