IN VITRO INDUCTION OF THE GAMMA GLOBIN GENE IN ERYTHROID CELLS DERIVED FROM CD133+ BY THALIDOMIDE AND SODIUM BUTYRATE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AHMADVAND MOHAMMAD; NOROUZINIA MEHRDAD; SOLEIMANI MASOOD; KAVIANI SAEED; ABROUN SAEID; DEHGHANIFARD ALI; MAHMOODINIA MAYMAND MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: GENETICS IN THE 3RD MILLENNIUM Year:2011 | Volume:9 | Issue:2 Page(s): 2373-2378

Download Full-Text

Persian Verion

View:

793

Download:

Cites:

Information Journal Paper

Title

IN VITRO INDUCTION OF THE GAMMA GLOBIN GENE IN ERYTHROID CELLS DERIVED FROM CD133+ BY THALIDOMIDE AND SODIUM BUTYRATE

Author(s)

Keywords

HEMOGLOBINQ2

SODIUM BUTYRATEQ2

THALIDOMIDEQ2

BETA-THALASSEMIAQ2

Abstract

Induction of fetal HEMOGLOBIN (HbF) is one of the most promising therapies of b-thalassemia and sickle cell disease, as HbF permanent induction can substantially ameliorate the clinical symptoms of these genetic disorders. Several classes of therapeutics have been implemented to induce U-globin expression in BETA-THALASSEMIA patients and subsequently to raise total HEMOGLOBIN levels. SODIUM BUTYRATE and Talidomide are two of the known agents. This study was conducted on erythroid cells differentiated from cord blood CD133 + stem cells. Four groups were designed and gamma globin was induced by THALIDOMIDE and SODIUM BUTYRATE treatment (100 mM concentrations). Gamma gene expression was evaluated using Quantitative Real Time PCR techniques. Among the treated groups with SODIUM BUTYRATE and THALIDOMIDE, it was shown that although these two agents both affected the induction of gamma and beta genes, THALIDOMIDE had a greater potency on beta cluster genes than SODIUM BUTYRATE. Our results showed that the pharmaceutical regime of THALIDOMIDE and SODIUM BUTYRATE could be useful for the treatment of b-Thalassemia and sickle cell patients because of the induction of the beta gene cluster.

Cites

No record.

References

No record.

Cite

APA: Copy

AHMADVAND, MOHAMMAD, NOROUZINIA, MEHRDAD, SOLEIMANI, MASOOD, KAVIANI, SAEED, ABROUN, SAEID, DEHGHANIFARD, ALI, & MAHMOODINIA MAYMAND, MARYAM. (2011). IN VITRO INDUCTION OF THE GAMMA GLOBIN GENE IN ERYTHROID CELLS DERIVED FROM CD133+ BY THALIDOMIDE AND SODIUM BUTYRATE. GENETICS IN THE 3RD MILLENNIUM, 9(2), 2373-2378. SID. https://sid.ir/paper/117229/en

Vancouver: Copy

AHMADVAND MOHAMMAD, NOROUZINIA MEHRDAD, SOLEIMANI MASOOD, KAVIANI SAEED, ABROUN SAEID, DEHGHANIFARD ALI, MAHMOODINIA MAYMAND MARYAM. IN VITRO INDUCTION OF THE GAMMA GLOBIN GENE IN ERYTHROID CELLS DERIVED FROM CD133+ BY THALIDOMIDE AND SODIUM BUTYRATE. GENETICS IN THE 3RD MILLENNIUM[Internet]. 2011;9(2):2373-2378. Available from: https://sid.ir/paper/117229/en

IEEE: Copy

MOHAMMAD AHMADVAND, MEHRDAD NOROUZINIA, MASOOD SOLEIMANI, SAEED KAVIANI, SAEID ABROUN, ALI DEHGHANIFARD, and MARYAM MAHMOODINIA MAYMAND, “IN VITRO INDUCTION OF THE GAMMA GLOBIN GENE IN ERYTHROID CELLS DERIVED FROM CD133+ BY THALIDOMIDE AND SODIUM BUTYRATE,” GENETICS IN THE 3RD MILLENNIUM, vol. 9, no. 2, pp. 2373–2378, 2011, [Online]. Available: https://sid.ir/paper/117229/en

Related Journal Papers