THERAPEUTIC EFFECTS OF ISOLATED SOY PROTEIN IN RATS WITH ACUTE LIVER FAILURE

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ERSHAD LANGEROUDI M.; EFTEKHARI M.H.; PANJEH SHAHIN M.R.; ORYAN A.; TABATABAEI H.R.

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Journal: Iranian Journal of Nutrition Sciences and Food Technology Year:2009 | Volume:4 | Issue:3 (14) Page(s): 55-62

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Title

THERAPEUTIC EFFECTS OF ISOLATED SOY PROTEIN IN RATS WITH ACUTE LIVER FAILURE

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Keywords

ACUTE LIVER FAILUREQ4

SOY PROTEIN ISOLATEQ4

CASEINQ2

Abstract

Background and Objectives: Proteins, as antioxidant compounds, can protect cells against free radical-induced damages. This study was conducted to investigate the protective and antioxidant effects of SOY PROTEIN ISOLATE (SPI) in ACUTE LIVER FAILURE in rats.Materials and Methods: In this experimental study, 48 rats were randomly divided into 3 groups. Groups 1 and 2 were put on a 20 % CASEIN- and group 3 on a 20 % SPI-diet. Liver injuries were induced by injection of dimethylnitrosamine (DMN) (30mg/mI per kg, ip) in groups 2 and 3.Biochemical parameters [serum aspartate amino-transferase (AST), alanine amino-transferees (ALT), alkaline phosphates (ALP), total protein, albumin, total bilirubin, and malondialdehyde (MDA)], as well as histopathological changes in liver tissue, were assessed at the end of the study. Results: Dietary SPI resulted in decrease in ALT (270.2±493.6 IU.L-1) (P<0.05) and increase in serum albumin (4.3±0.7g.dl-1) and MDA (8.5±1.7 nmol.m-1) levels (P<0.05). SPI did not have significant effect on other factors. Histopathological findings indicated that SPI led to improvement of the damage and rapid hepatocyte regeneration.Conclusion: Results of our study suggest that an SPI diet can improve acute liver damage and reduce DMN-induced complications.

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APA: Copy

ERSHAD LANGEROUDI, M., EFTEKHARI, M.H., PANJEH SHAHIN, M.R., ORYAN, A., & TABATABAEI, H.R.. (2009). THERAPEUTIC EFFECTS OF ISOLATED SOY PROTEIN IN RATS WITH ACUTE LIVER FAILURE. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, 4(3 (14)), 55-62. SID. https://sid.ir/paper/121465/en

Vancouver: Copy

ERSHAD LANGEROUDI M., EFTEKHARI M.H., PANJEH SHAHIN M.R., ORYAN A., TABATABAEI H.R.. THERAPEUTIC EFFECTS OF ISOLATED SOY PROTEIN IN RATS WITH ACUTE LIVER FAILURE. JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY[Internet]. 2009;4(3 (14)):55-62. Available from: https://sid.ir/paper/121465/en

IEEE: Copy

M. ERSHAD LANGEROUDI, M.H. EFTEKHARI, M.R. PANJEH SHAHIN, A. ORYAN, and H.R. TABATABAEI, “THERAPEUTIC EFFECTS OF ISOLATED SOY PROTEIN IN RATS WITH ACUTE LIVER FAILURE,” JOURNAL OF NUTRITION SCIENCES & FOOD TECHNOLOGY, vol. 4, no. 3 (14), pp. 55–62, 2009, [Online]. Available: https://sid.ir/paper/121465/en

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