EVALUATION OF SLC30A8 GENE POLYMORPHISM (RS13266634) DISTRIBUTION IN PATIENTS WITH DIABETES TYPE 2 IN WEST MAZANDARAN-IRAN

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SHOKRZADEH MOHAMMAD; MOHAMMAD POUR ABBAS; GERAMI MAHYAR; DARYAEI MOSTAFA; ABBASI ROSHAN MEHDI; RAJABI SAHNE SARAEE MEHRAN

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Journal: Jundishapur Scientific Medical Journal Year:2018 | Volume:17 | Issue:1 Page(s): 63-70

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Title

EVALUATION OF SLC30A8 GENE POLYMORPHISM (RS13266634) DISTRIBUTION IN PATIENTS WITH DIABETES TYPE 2 IN WEST MAZANDARAN-IRAN

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Keywords

TYPE 2 DIABETEQ2

RS13266634 POLYMORPHISMQ1

SLC30A8 GENEQ1

PCR-RFLPQ2

Abstract

Background and Objective: TYPE 2 DIABETEs mellitus is a complex heterogeneous group of metabolic disorders characterized by increased levels of blood glucose due to impairment in insulin action and/or insulin secretion. The SLC30A8 GENE is considered as one of the most important candidate genes of TYPE 2 DIABETEs. The objective of this study was to evaluate the distributuion of this gene among our patients in Mazandaran, Iran.Subjects and Methods: In this case-control study, 135 patients and 76 healthy subjects were recruited. Five ml of peripheral blood of diabetics and healthy subjects (controls) was collected in EDTA-containing tubes. Genomic DNA was extracted using salting-out method and genotype and allele frequencies of the RS13266634 POLYMORPHISM were investigated using PCR-RFLP method.Results: Genotype and allele frequencies of the RS13266634 POLYMORPHISM differed significantly between type 2 diabetic patients and non-diabetic subjects (P=0.0003 and P=0.0664, respectively). The frequency of C allele was 89% in TYPE 2 DIABETEs group and 67% in non-diabetic subjects, and this allele was significantly associated with TYPE 2 DIABETEs risk (OR=10.0, 95% CI 1.9124-591.3058, 2.924- 924.239).Conclusion: Our results confirm the association between the RS13266634 POLYMORPHISM of the SLC30A8 GENE and the increased risk of TYPE 2 DIABETEs among the West Mazandaran population.

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APA: Copy

SHOKRZADEH, MOHAMMAD, MOHAMMAD POUR, ABBAS, GERAMI, MAHYAR, DARYAEI, MOSTAFA, ABBASI ROSHAN, MEHDI, & RAJABI SAHNE SARAEE, MEHRAN. (2018). EVALUATION OF SLC30A8 GENE POLYMORPHISM (RS13266634) DISTRIBUTION IN PATIENTS WITH DIABETES TYPE 2 IN WEST MAZANDARAN-IRAN. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, 17(1 ), 63-70. SID. https://sid.ir/paper/12321/en

Vancouver: Copy

SHOKRZADEH MOHAMMAD, MOHAMMAD POUR ABBAS, GERAMI MAHYAR, DARYAEI MOSTAFA, ABBASI ROSHAN MEHDI, RAJABI SAHNE SARAEE MEHRAN. EVALUATION OF SLC30A8 GENE POLYMORPHISM (RS13266634) DISTRIBUTION IN PATIENTS WITH DIABETES TYPE 2 IN WEST MAZANDARAN-IRAN. JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL[Internet]. 2018;17(1 ):63-70. Available from: https://sid.ir/paper/12321/en

IEEE: Copy

MOHAMMAD SHOKRZADEH, ABBAS MOHAMMAD POUR, MAHYAR GERAMI, MOSTAFA DARYAEI, MEHDI ABBASI ROSHAN, and MEHRAN RAJABI SAHNE SARAEE, “EVALUATION OF SLC30A8 GENE POLYMORPHISM (RS13266634) DISTRIBUTION IN PATIENTS WITH DIABETES TYPE 2 IN WEST MAZANDARAN-IRAN,” JUNDISHAPUR SCIENTIFIC MEDICAL JOURNAL, vol. 17, no. 1 , pp. 63–70, 2018, [Online]. Available: https://sid.ir/paper/12321/en

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